| Project/Area Number |
15K10627
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
YASUI TAKAHIRO 名古屋市立大学, 大学院医学研究科, 教授 (40326153)
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| Co-Investigator(Kenkyū-buntansha) |
田口 和己 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (00595184)
郡 健二郎 名古屋市立大学, その他部局等, 学長 (30122047)
安藤 亮介 名古屋市立大学, 医学(系)研究科(研究院), その他 (30381867)
戸澤 啓一 名古屋市立大学, 大学院医学研究科, 教授 (40264733)
岡田 淳志 名古屋市立大学, 大学院医学研究科, 講師 (70444966)
濱本 周造 名古屋市立大学, 大学院医学研究科, 講師 (80551267)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 尿路結石 / 酸化ストレス / ミトコンドリア / マクロファージ / ゲノムワイド関連解析 |
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| Outline of Final Research Achievements |
(1) Development of medicine and biomarkers focusing on the mitochondrial injury of renal tubule cells.:The oxalic acid precursor was administered to the knockout mouse of Cyclophilin D (cypD), and the formation of stone and the molecular mechanism were elucidated. Compared to in wild-type, mitochondrial injury and stone formation were small in CypD knockout mice.
(2) Identification of new related genes and development of risk diagnosis method.:We tried to establish a diagnosis method of onset risk from the gene region identified by comprehensive human genome-wide association analysis. The related genes were examined using a multiplex analysis system. M1 macrophage-related substances decreased in healthy subjects and M2 macrophage-related substances decreased in stone patients.
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