Basic study for ovulation induction using novel hypothalamic peptide analogues in suppressed hypothalamic GnRH secretion
| Project/Area Number |
15K10673
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MATSUZAKI Toshiya 徳島大学, 大学院医歯薬学研究部(医学系), 准教授 (70294692)
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| Co-Investigator(Kenkyū-buntansha) |
苛原 稔 徳島大学, 大学院医歯薬学研究部(医学系), 教授 (20160070)
岩佐 武 徳島大学, 病院, 特任准教授 (00707903)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | GnRH / キスペプチン / KNDyニューロン / NKB / ダイノルフィン / センクタイド / nor-BNI / nor-MNI |
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| Outline of Final Research Achievements |
We aimed to determine whether stimulation of neurokinin B (NKB)/neurokinin 3 receptor (NK3R) signaling and inhibition of dynorphin (Dyn)/kappa-opioid receptor (KOR) signaling recover LH secretion that is suppressed by acute fasting in male rats and male mice. Mature male rats were injected saline and senktide (20g/kg), a NK3R agonist, or nor-BNI (800g/kg), a KOR antagonist ip after 72h fasting. Mature male mice were injected multiple doses of senktide after 48h fasting. All three studies showed significantly lower LH concentration in fasted groups. Senktide recovered LH level suppressed by acute fasting in male mice, and nor-BNI also recovered LH level in male rats. These results suggest that stimulation of NKB/NK3R signaling and attenuation of Dyn/KOR signaling could recover suppressed LH secretion under acute fasting condition in male rodents.
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Report
(4 results)
Research Products
(54 results)
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[Journal Article] Multiple Androgen Biosynthesis Pathways Are Operating in Women with Polycystic Ovary Syndrome.2016
Author(s)
Saito K, Matsuzaki T, Iwasa T, Miyado M, Saito H, Hasegawa T, Homma K, Inoue E, Kubota T, Irahara M, Ogata T, Fukami M
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Journal Title
J Steroid Biochem Mol Biol
Volume: 158
Pages: 31-37
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] The responses of hypothalamic NPY and OBRb mRNA expression to food deprivation develop during the neonatal-prepubertal period and exhibit gender differences in rats.2015
Author(s)
Matsuzaki T, Iwasa T, Tungalagsuvd A, Munkhzaya M, Kawami T, Yamasaki M, Murakami M, Kato T, Kuwahara A, Yasui T, Irahara M.
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Journal Title
Int J Dev Neurosci.
Volume: 41
Issue: 1
Pages: 63-67
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Developmental changes in hypothalamic oxytocin and oxytocin receptor mRNA expression and their sensitivity to fasting in male and female rats.2015
Author(s)
Matsuzaki T, Iwasa T, Munkhzaya M, Tungalagsuvd A, Kawami T, Murakami M, Yamasaki M, Yamamoto Y, Kato T, Kuwahara A, Yasui T, Irahara M.
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Journal Title
Int J Dev Neurosci.
Volume: 41
Issue: 1
Pages: 105-109
DOI
Related Report
Peer Reviewed / Open Access
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