Relationship between placenta accreta and mRNA/micro RNA

• Project/Area Number: 15K10676
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Nagasaki University
• Principal Investigator: YOSHIDA Atsushi 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (50432977)
• Co-Investigator(Kenkyū-buntansha): 三浦 清徳 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (00363490)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 癒着胎盤 / 術中超音波 / 胎盤特異的mRNA/miRNA / 前置胎盤 / 分子マーカー / micro RNA / 産婦人科 / microRNA / 母体血漿 / C19MC / 胎盤特異的

Outline of Final Research Achievements

1) In order to estimate the risk of placenta accreta at early pregnancy, we comprehensively identified placenta-specific genes flowing into maternal blood at early pregnancy. 2) The findings of intraoperative ultrasonography have made it possible to deny the possibility of adherent placenta that is difficult to remove.

Academic Significance and Societal Importance of the Research Achievements

妊娠初期の時点から分子マーカーを用いて癒着胎盤のリスクをスクリーニングし、妊娠16週以降の超音波検査で癒着胎盤の程度を評価するという新たなアプローチを前方視的に検証することを目的としたが、症例数
に限りがあり今回は検討できなかた。今後研究を継続して症例を追加することで、癒着胎盤の非侵襲的な妊婦検診法として受け入れられやすく、将来の臨床応用が十分に期待できる。

Research Products

• [Journal Article] ダグラス窩に嵌頓した卵巣腫瘍合併妊娠 (2016)
  • Author(s): 塚本大空、吉田敦、増﨑英明
  • Journal Title: ペリネイタルケア Volume: 35 Pages: 521-525
• [Journal Article] 絨毛膜瘤 (2016)
  • Author(s): 川下さやか，吉田敦，増﨑英明
  • Journal Title: ペリネイタルケア Volume: 35 Pages: 617-621
• [Journal Article] Authors' reply re: Transverse uterine fundal incision for placenta praevia with accreta, involving the entire anterior uterine wall: a case series. (2015)
  • Author(s): Nishijima K, Orisaka M, Takahashi J, Yamamoto M, Nakago S, Yoshida A, Masuzaki H, Kotsuji F, Yoshida Y.
  • Journal Title: British journal of obstetrics and gynaecology Volume: 122 Issue: 13 Pages: 1844-5
  • DOI: 10.1111/1471-0528.13610
  • Peer Reviewed
• [Journal Article] Effect of labor on plasma concentrations and postpartum clearance of cell-free, pregnancy-associated, placenta-specific microRNAs (2015)
  • Author(s): Morisaki S, Miura K, Higashijima A, Abe S, Miura S, Hasegawa Y, Yoshida A, Kaneuchi M, Yoshiura K, Masuzaki H
  • Journal Title: Prenat Diagn Volume: 35 Issue: 1 Pages: 44-50
  • DOI: 10.1002/pd.4479
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Circulating levels of maternal plasma cell-free miR-21 are associated with maternal body mass index and neonatal birth weight. (2015)
  • Author(s): Miura K, Higashijima A, Hasegawa Y, Abe S, Miura S, Fuchi N, Murakami Y, Kinoshita A, Yoshida A, Kaneuchi M, Yoshiura KI, Masuzaki H.
  • Journal Title: Prenatal Diagnosis Volume: 35 Issue: 5 Pages: 509-511
  • DOI: 10.1002/pd.4509
  • Peer Reviewed
• [Remarks] 長崎大学医学部産婦人科
  • URL: http://www.med.nagasaki-u.ac.jp/gyneclgy/
• [Remarks] 長崎大学病院産婦人科
  • URL: http://www.med.nagasaki-u.ac.jp/gyneclgy/