Natural conception and recurrence in women with endometrioma following surgery may be related to pollinosis.
| Project/Area Number |
15K10691
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Research Collaborator |
IGARASHI MASAO 群馬大学, 医学部, 名誉教授
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 子宮内膜症 / 再発 / 妊娠 / 花粉症 / 卵巣チョコレート嚢胞 / 術後再発 / アポトーシス / エピナスチン / 術後自然妊娠 / 不妊症 / 3エチルピリジン(3EP) / CD44 / テネイシン / プロゲステロン受容体 |
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| Outline of Final Research Achievements |
Pollinosis and epinastine may be related to natural conception in women with pollinosis and endometrioma following surgeries. One hundred and nineteen child-bearing or infertile women with EMoma following a laparoscopic surgery were retrospectively enrolled. We excluded IVF-ET pregnancies and retrospectively compared patient backgrounds including incidence of pollinosis and reproductive outcomes for 3 years between the natural conception group (n=43) and the non-conception group (n=50). Natural conception occurred around 15 months following surgery, while users of epinastine were pregnant around 2.7 months following the onset of administration. Non-users of epinastine were pregnant around 15 months following surgery (P=0.051). EMoma patients with pollinosis were easy to get recurrence of EMoma (3.3 fold) and natural conception (3.9 fold) following surgery. Our results suggest that pollinosis may be complicatedly related to recurrence of EMoma and natural conception following surgery.
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Report
(4 results)
Research Products
(22 results)
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[Presentation] Epinastine, a histamine H1 receptor antagonist, may contribute to natural conception in the women with pollinosis and endometrioma following surgeries2017
Author(s)
Toshio Igarashi, Akari Kusamoto, Masaki Morioka, Hiroe Nakamura, Takahiro Koso, Yasuaki Nakamura, Tetsushi Tsuruga, Masaru Hayashi, Shan-Guang Liang.
Organizer
第13回 世界子宮内膜症会議 WCE
Related Report
Int'l Joint Research
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[Presentation] DIENOGEST DOWN-REGULATES GLANDULAR PROGESTERONE RECEPTORS IN OVARIAN ENDOMETRIOMAS AND VAGINAL POLYPOID ENDOMETRIOSIS.2016
Author(s)
Toshio Igarashi1, Kazuto Yamazaki2, Ayako Komura1, Masaki Morioka1, Yoshihide Sagawa1, Hiroe Nakamura1, Takahiro Koso1, Yasuaki Nakamura1, Tetsushi Tsuruga1, Masaru Hayashi1, Yasuo Ishida2, and Shan-Guang Liang1
Organizer
5th Asian Conference on Endometriosis
Place of Presentation
大阪国際会議場
Year and Date
2016-09-23
Related Report
Int'l Joint Research
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