|Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
|Outline of Final Research Achievements
Interleukin-15 (IL-15) is a cytokine that acts on NK cells and T cells and induces cell proliferation and activation. Evaluation of the effect on STAT5 phosphorylation of 15 compounds selected by in silico screening showed strong antagonistic (inhibitory) effect (inhibition rate 32%) with compound N43. In addition, weak inhibitory effect was observed for compounds N6, N15 and N35. In future, we aim to establish an evaluation system utilizing a sandwich ELISA method in the future.