| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The serum levels of phosphorus are regulated by FGF23. FGF23, which is mainly produced in bone, inhibits reabsorption of phosphorus in kidney, and inhibits absorption of calcium and phosphorus in intestine by inhibiting the production of active vitamin D. Galnt3（UDP-N-acetyl-D-galactosamine:polypeptide N-acetyl-D-galactosaminyltransferase 3）inhibits the processing of FGF23 by mucin type O-glycosylation of FGF23, and maintains the activity of FGF23. Runx2 induced Galnt3 expression in osteoblasts and chondrocytes. Runx2 was involved partly in the regulation of the serum levels of phosphorus through the regulation of Galnt3 expression.
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