| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The aim of this study is to develop a method for inhibiting oral colonization of Staphylococcus aureus (Sa) . We set up 2 researches both colonization mechanism and searching antibacterial factor toward development of multidrug resistant Staphylococcus aureus (MRSA) in oral cavity. We revealed that glycyrrhetic acid (GRA) and succinic acid (GR - SU) exerted antibacterial activity againist clinical isolated MRSA. We discovered the novel drug resistance mechanism of MRSA by exposing sub-MIC concentration on nisin, a bacteriocin derived from lactic acid bacteria.
From these experiments, we discovered a novel naturally occurring antimicrobial substance effective for MRSA and a novel drug resistance mechanism of MRSA against antibacterial substances of bacteria, and it will be important to conduct fundamental research on inhibition of MRSA colonization in oral cavity in the future.
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