Analysis of the sweet receptor as an energy sensor
| Project/Area Number |
15K11045
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 味覚 / 甘味受容体 / ミラクリン / TAS1R2/TAS1R3 / 味覚修飾物質 |
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| Outline of Final Research Achievements |
Sweet taste is mediated by the sweet taste receptor, TAS1R2 + TAS1R3, with multiple biding sites for structurally diverse chemical substances. Using the sweet receptor assay in heterologously transfected HEK293 cells, we examined the sweet-modifying effect of miraculin. As a result, intracellular acidification was found to be required for the effect of miraculin.
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Report
(4 results)
Research Products
(15 results)
