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Analysis of cathepsin K inhibitor in murine jaw bone metastasis model of oral cancer

Research Project

Project/Area Number 15K11077
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionSaga University

Principal Investigator

DANJO Atsushi  佐賀大学, 医学部, 准教授 (80452712)

Co-Investigator(Kenkyū-buntansha) 山下 佳雄  佐賀大学, 医学部, 教授 (50322300)
下平 大治  佐賀大学, 医学部, 助教 (70594844)
鶴岡 祥子  佐賀大学, 医学部, 助教 (30612353)
井上 将成  佐賀大学, 医学部, 助教 (10720203)
後藤 昌昭  佐賀大学, その他部局等, 理事 (10145211)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords口腔癌 / 顎骨浸潤 / カテプシンK / シスタチンC / 骨代謝 / 骨浸潤
Outline of Final Research Achievements

The treatment of local progress oral cancer with invasion to jawbone causes the functional disorder such as the deformity of the face or chewing ability, because of resection of the jaw bone. It is necessary to control the osteoclast functions which performs bone resorption to control jawbone invasion of oral cancer. We analyzed the effect of cathepsin K inhibitors which control bone resorption activities in osteoclasts using a jawbone invasion experimental model of oral squamous cell carcinoma in this study. The cathepsin K inhibitors did not affect the increase of osteoblasts and the osteoclasts by the in vitro experiment, but decreased the number of the human oral squamous cell carcinoma cells. There was the difference with the drug in the bone resorption inhibition effect of the cathepsin K inhibitors by the in vivo experiment, and the significant difference was not recognized.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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