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Analysis of migration factor expressed in dendritic cells during metal allergy development

Research Project

Project/Area Number 15K11161
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Prosthodontics/ Dental materials science and
Research InstitutionThe University of Tokushima

Principal Investigator

WATANABE Megumi  徳島大学, 病院, 講師 (40380050)

Co-Investigator(Kenkyū-buntansha) 後藤 崇晴  徳島大学, 大学院医歯薬学研究部(歯学系), 助教 (00581381)
Research Collaborator ISHIMARU Naozumi  
WL HAVRAN  
UG KNAUS  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords歯科用金属アレルギー / 樹状細胞 / 上皮角化細胞 / 細胞遊走 / 金属アレルギー / ケラチノサイト / TSLP/TSLPR
Outline of Final Research Achievements

The aim of this study is to clarify the interactions between dendritic cells and keratinocytes during the development of metal allergy. We focused on the interactions of TSLP in keratinocytes and TSLPR in dendritic cells. Expressions of both TSLP and TSLPR in cells stimulated with nickel were increased subsequently. Significant decrease of ear swellings was observed in mice which were injected with TSLPR siRNA in ear skin before the injection of nickel. Therefore, interactions between TSLP in keratinocytes and TSLPR in dendritic cells may play an important role in development of metal allergy and these interactions have a possibility of using for diagnosis or treatment for metal allergy.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (5 results)

All 2018 2017 2016 2015

All Presentation (5 results) (of which Invited: 3 results)

  • [Presentation] 義歯材料とアレルギー2018

    • Author(s)
      渡邉恵
    • Organizer
      日本義歯ケア学会 第10回学術大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ニッケルで刺激したケラチノサイトと樹状細胞におけるPlexin-Semaphorinの動態解析2017

    • Author(s)
      南憲一,渡邉 恵,市川哲雄
    • Organizer
      (公社)日本補綴歯科学会 第126回学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 基礎研究からみた金属アレルギー2016

    • Author(s)
      渡邉 恵
    • Organizer
      第8回 一般社団法人 日本メタルフリー歯科学会学術大会
    • Place of Presentation
      愛知学院大学(愛知県名古屋市)
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 金属アレルギーの発症と免疫2015

    • Author(s)
      渡邉恵
    • Organizer
      (公社)日本補綴歯科学会 関西支部総会・学術大会
    • Place of Presentation
      兵庫医療大学(兵庫県神戸市)
    • Year and Date
      2015-11-08
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 金属アレルギーの病態2015

    • Author(s)
      渡邉恵
    • Organizer
      (公社)日本補綴歯科学会第124回学術大会
    • Place of Presentation
      大宮ソニックシティ(埼玉県さいたま市)
    • Year and Date
      2015-05-30
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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