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adaptive bone remodeling on micro-structurally optimized titanium implant

Research Project

Project/Area Number 15K11222
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dental engineering/Regenerative dentistry
Research InstitutionShowa University

Principal Investigator

Shibata Yo  昭和大学, 歯学部, 講師 (30327936)

Co-Investigator(Kenkyū-buntansha) 鈴木 大  昭和大学, 歯学部, 講師 (00585797)
宮崎 隆  昭和大学, 歯学部, 教授 (40175617)
谷本 安浩  日本大学, 松戸歯学部, 准教授 (40312045)
美島 健二  昭和大学, 歯学部, 教授 (50275343)
山田 篤  昭和大学, 歯学部, 講師 (50407558)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsチタン / インプラント / リモデリング / ナノインデンテーション / 表面分析 / バイオメカニクス / 陽極酸化 / 細胞 / チタン‐ジルコニウム合金 / 適応的リモデリング
Outline of Final Research Achievements

The purpose of this study is to investigate the mechanical requirements of tissue- implant interface. The interface of spark anodized titanium- bone ingrowth likely enables a functionally graded Young’s modulus, thereby allowing reduction of stress shielding. The understanding of complex mechanical bone behavior and size-dependent properties ranging from nano- to a mesoscopic level are essential in the biomechanical optimization of implants. The requirements of regenerated tissue at the interface include high strength, fracture toughness related to ductility, and time-dependent energy dissipation and/or elastic-plastic stress distribution. Moreover, a strong relationship between strain signals and peri-implant tissue turnover could be expected, so that ideal implant biomechanics allows longevity via adaptive bone remodeling.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (24 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (6 results) Journal Article (8 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 8 results,  Open Access: 5 results,  Acknowledgement Compliant: 4 results) Presentation (8 results) (of which Int'l Joint Research: 5 results,  Invited: 1 results) Remarks (2 results)

  • [Int'l Joint Research] The University of Sydney(Australia)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] The University of Otago(New Zealand)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] オタゴ大学(ニュージーランド)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] ジェームスクック大学(オーストラリア)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] University of Melbourne(Australia)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research] University of Otago(New Zealand)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Nanoindentation time-dependent deformation/recovery suggestive of methylglyoxal induced glycation in calcified nodules2017

    • Author(s)
      Rodriguez Reena、Yoshimura Kentaro、Shibata Yo、Miyamoto Yoichi、Tanaka Reina、Uyama Risa、Sasa Kiyohito、Suzuki Dai、Miyazaki Takashi、Kamijo Ryutaro
    • Journal Title

      Nanomedicine

      Volume: 13 Issue: 8 Pages: 2545-2553

    • DOI

      10.1016/j.nano.2017.07.003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Surface quality of yttria-stabilized tetragonal zirconia polycrystal in CAD/CAM milling, sintering, polishing and sandblasting processes2017

    • Author(s)
      Alao A.R., Stoll R., Song X.F., Miyazaki T., Hotta Y., Shibata Y., Yin L.
    • Journal Title

      Journal of the Mechanical Behavior of Biomedical Materials

      Volume: 65 Pages: 102-116

    • DOI

      10.1016/j.jmbbm.2016.08.021

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Histomorphometric and histologic evaluation of titanium-zirconium (aTiZr) implants with anodized surfaces.2016

    • Author(s)
      6.Sharma A., McQuillan A.J., Shibata Y., Sharma L.A., Waddell J.N., Duncan W.J.
    • Journal Title

      Journal of Materials Science: Materials in Medicine

      Volume: 27 Issue: 5 Pages: 86-86

    • DOI

      10.1007/s10856-016-5695-4

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Spark anodization of titanium-zirconium alloy: surface characterization and bioactivity assessment.2015

    • Author(s)
      8.Sharma A., McQuillan A.J., Sharma L.A., Waddell J.N., Shibata Y., Duncan W.J.
    • Journal Title

      Journal of Materials Science: Materials in Medicine

      Volume: 26 Issue: 8 Pages: 221-221

    • DOI

      10.1007/s10856-015-5555-7

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Surface topography, hardness, and frictional properties of GFRP for esthetic orthodontic wires2015

    • Author(s)
      Inami T., Tanimoto Y., Yamaguchi M., Shibata Y., Nishiyama N., Kasai K.
    • Journal Title

      Journal of Biomedical Materials Research Part B: Applied Biomaterials

      Volume: 103 Issue: 1 Pages: 88-95

    • DOI

      10.1002/jbm.b.33372

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Bone aging by advanced glycation end products: multi-scale mechanical analysis.2015

    • Author(s)
      9.Ganeko K., Masaki C., Shibata Y., Kondo Y., Mukaibo T., Nakamoto T., Miyazaki T., Hosokawa R.
    • Journal Title

      Journal of Dental Research

      Volume: 94 Issue: 12 Pages: 1684-1690

    • DOI

      10.1177/0022034515602214

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A review of improved fixation methods for dental implants. Part I: Surface optimization for rapid osseointegration2015

    • Author(s)
      Shibata Y., Tanimoto Y.
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 59 Issue: 1 Pages: 20-33

    • DOI

      10.1016/j.jpor.2014.11.007

    • NAID

      130007936698

    • ISSN
      1883-1958, 1883-9207
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A review of improved fixation methods for dental implants. Part II: Biomechanical integrity at bone–implant interface2015

    • Author(s)
      Shibata Y., Tanimoto Y., Maruyama N., Nagakura M.
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 59 Issue: 2 Pages: 84-95

    • DOI

      10.1016/j.jpor.2015.01.003

    • NAID

      130007936685

    • ISSN
      1883-1958, 1883-9207
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Enamel regeneration via mild annealing2018

    • Author(s)
      Yo Shibata
    • Organizer
      The University of Sydney CAMT Annual Workshop
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Nanoindentation Characterization of Regenerated Tooth Enamel2017

    • Author(s)
      Shibata Y., Tanaka R., Wurihan, Zhou J., Tobe T., Yamamoto M., and Miyazaki T.
    • Organizer
      7th ICMOBT
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dynamic mechanical analysis of dentin-bonding interface prepared by a self-etching primer2016

    • Author(s)
      Zhou J, Tanaka R, Shibata Y, Gao P, Miyazaki T
    • Organizer
      International Dental Materials Congress 2016
    • Place of Presentation
      インドネシア
    • Year and Date
      2016-11-04
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Stress-strain behavior of bleached enamel stored in a high ionic strength solution2016

    • Author(s)
      Tanaka R, Zhou J, Shibata Y, and Miyazaki T
    • Organizer
      International Dental Materials Congress 2016
    • Place of Presentation
      インドネシア
    • Year and Date
      2016-11-04
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Bone micro-mechanical properties related to mimetic aging processes2015

    • Author(s)
      Y. Shibata, N. Maruyama, Y. Tanimoto, K. Maki, and T. Miyazaki
    • Organizer
      6th International Conference on the Mechanics of Biomaterials and Tissues
    • Place of Presentation
      USA, Hawaii
    • Year and Date
      2015-12-06
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] セルフエッチングプライマーによる樹脂含浸層の力学的特性2015

    • Author(s)
      周 君,田中 玲奈,柴田 陽,宮﨑 隆
    • Organizer
      第66回日本歯科理工学会学術講演会
    • Place of Presentation
      千葉,船堀
    • Year and Date
      2015-10-03
    • Related Report
      2015 Research-status Report
  • [Presentation] α-klotho遺伝子欠損マウスをモデルとした老化による皮質骨の物理的特性2015

    • Author(s)
      丸山範子,柴田 陽,宮﨑 ,宮﨑 隆,槇宏太郎
    • Organizer
      第66回日本歯科理工学会学術講演会
    • Place of Presentation
      千葉,船堀
    • Year and Date
      2015-10-03
    • Related Report
      2015 Research-status Report
  • [Presentation] ナノインデンテーション法による漂白エナメル質の物性解析2015

    • Author(s)
      田中玲奈,柴田 陽,糸瀬明希 ,宮﨑 隆
    • Organizer
      第66回日本歯科理工学会学術講演会
    • Place of Presentation
      千葉,船堀
    • Year and Date
      2015-10-03
    • Related Report
      2015 Research-status Report
  • [Remarks] Goole Scholar Citation

    • URL

      http://scholar.google.co.jp/citations?hl=ja&user=IZMDGX0AAAAJ&view_op=list_works&sortby=pubdate

    • Related Report
      2015 Research-status Report
  • [Remarks] Researcher ID

    • URL

      http://www.researcherid.com/rid/C-7466-2009

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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