Novel immunotherapy with HDAC inhibitor and OK-432 targeting PD-1
| Project/Area Number |
15K11293
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
OHE Go 徳島大学, 病院, 助教 (60432762)
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| Co-Investigator(Kenkyū-buntansha) |
玉谷 哲也 徳島大学, 病院, 講師 (30274236)
高丸 菜都美 徳島大学, 病院, 助教 (40513031)
永井 宏和 東北大学, 歯学研究科, 准教授 (50282190)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | PD-L1 / PD-1 / 免疫チェックポイント / OK-432 / 口腔癌 / 免疫チェックポイント阻害剤 / 口腔扁平上皮癌 |
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| Outline of Final Research Achievements |
Tumor bearing mice were treated with anti PD-L1 Ab and/or OK-432, and the mechanism of antitumoe effect was analyzed.PD-L1 was not expressed on untreated SCCVII cells, but after adding IFN-γ, PD-L1 was expressed. anti PD-L1 Ab couldn't demonstrated directly effective on SCCVII proliferation (MTT assay). Combination therapy anti PD-L1 Ab and OK-432 inhibited tumor growth of SCCVII bearing mice.
It was suggested that combination therapy anti PD-L1 Ab and OK-432 could be an effective therapy against oral cancer.
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Report
(4 results)
Research Products
(1 results)
