role of melatonin in periodontal disease

• Project/Area Number: 15K11392
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Periodontology
• Research Institution: The University of Tokushima
• Principal Investigator: HOSOKAWA Ikuko 徳島大学, 大学院医歯薬学研究部(歯学系), 助教 (50707908)
• Co-Investigator(Kenkyū-buntansha): 中西 正 徳島大学, 大学院医歯薬学研究部(歯学系), 准教授 (00217770) ; 細川 義隆 徳島大学, 病院, 講師 (90346601)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 歯周炎 / メラトニン / MMP-1 / CXCL10 / IL-27 / ケモカイン / TNF-α / MMP

Outline of Final Research Achievements

We examined the effect of melatonin on CXCL10 and MMP-1 productions from IL-1β-stimulated human periodontal ligament cells (HPDLC) in this study. We found that melatonin could inhibit CXCl10 and MMP-1 producutions from IL-1β-stimulated HPDLC. Therefore, melatonin could the initiation and progression of periodontal disease by controlling chemokine and MMP production in periodontal lesions.

Research Products

• [Journal Article] Effects of Theaflavin on Chemokine Production in TNF-α-stimulated Oral Epithelial Cells (2018)
  • Author(s): 細川義隆、細川育子、尾崎和美、松尾敬志
  • Journal Title: The Japanese Journal of Conservative Dentistry Volume: 61 Issue: 1 Pages: 10-16
  • DOI: 10.11471/shikahozon.61.10
  • NAID: 130006406446
  • ISSN: 0387-2343, 2188-0808
  • Peer Reviewed / Open Access
• [Journal Article] IL-29 Enhances CXCL10 Production in TNF-α-stimulated Human Oral Epithelial Cells. (2017)
  • Author(s): Hosokawa Y, Hosokawa I, Shindo S, Ozaki K, Matsuo T.
  • Journal Title: Immunological investigations Volume: 46 Issue: 6 Pages: 615-624
  • DOI: 10.1080/08820139.2017.1336176
  • NAID: 120006543832
  • Peer Reviewed
• [Journal Article] IL-27 Modulates Chemokine Production in TNF-α -Stimulated Human Oral Epithelial Cells. (2017)
  • Author(s): Hosokawa Y, Hosokawa I, Ozaki K, Matsuo T.
  • Journal Title: Cell Physiol Biochem. Volume: 43 Issue: 3 Pages: 1198-1206
  • DOI: 10.1159/000481760
  • NAID: 120006550809
  • Peer Reviewed / Open Access
• [Journal Article] Shikonin Inhibits Inflammatory Cytokine Production in Human Periodontal Ligament Cells (2016)
  • Author(s): Shindo S, Hosokawa Y, Hosokawa I, Ozaki K, Matsuo T
  • Journal Title: Inflammation Volume: 39 Pages: 1124-1129
  • DOI: 10.1007/s10753-016-0344-0
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Metatonin Inhibits CXCL10 and MMP-1 Production in IL-1β-stimulated Human Periodontal Ligament Cells (2016)
  • Author(s): Ikuko Hosokawa, Yoshitaka Hosokawa, Satoru Shindo, Kazumi Ozaki, Takashi Matsuo
  • Journal Title: Inflammation Volume: 39 Issue: 4 Pages: 1520-1526
  • DOI: 10.1007/s10753-016-0386-3
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Alkannin inhibits CCL3 and CCL5 production in human periodontal ligament cells (2016)
  • Author(s): Hosokawa Y, Hosokawa I, Shindo S, Ohta Y, Ozaki K, Matsuo T
  • Journal Title: Cell Biology International Volume: 40 Issue: 12 Pages: 1380-1385
  • DOI: 10.1002/cbin.10692
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Gomisin N Decreases Inflammatory Cytokine Production in Human Periodontal Ligament Cells (2016)
  • Author(s): Hosokawa Y, Hosokawa I, Shindo S, Ozaki K, Matsuo T
  • Journal Title: Inflammation Volume: 40 Issue: 2 Pages: 360-365
  • DOI: 10.1007/s10753-016-0482-4
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] IL-4 modulates CCL11 and CCL20 productions from IL-1β-stimulated human periodontal ligament cells (2016)
  • Author(s): Yoshitaka Hosokawa, Ikuko Hosokawa, Satoru Shindo, Kazumi Ozaki, Takashi Matsuo
  • Journal Title: Cellular Physiology and Biochemistry Volume: 38 Issue: 1 Pages: 153-159
  • DOI: 10.1159/000438617
  • NAID: 120006550808
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Calcitriol supressed inflammatory reactions in IL-1β-stimulated human periodontal ligament cells (2015)
  • Author(s): Yoshitaka Hosokawa, Ikuko Hosokawa, Satoru Shindo, Kazumi Ozaki, Takashi Matsuo
  • Journal Title: Inflammation Volume: 38 Issue: 6 Pages: 2252-2258
  • DOI: 10.1007/s10753-015-0209-y
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] IL-29はヒト口腔上皮細胞のCXCL10産生を増強する (2017)
  • Author(s): 細川義隆、細川育子、尾崎和美、松尾敬志
  • Organizer: 第147回日本歯科保存学会2017年度秋季学術大会
• [Presentation] IL-29はTNF-αが誘導するヒト口腔上皮細胞のCXCL10産生を増強する (2017)
  • Author(s): 細川義隆、細川育子、尾崎和美、松尾敬志
  • Organizer: 日本歯周病学会60周年記念京都大会
• [Presentation] Gomisin Nはヒト歯根膜由来細胞の炎症性サイトカイン産生を抑制する (2016)
  • Author(s): 細川義隆、細川育子、進藤智、尾崎和美、松尾敬志
  • Organizer: 日本歯科保存学会2016年度秋季保存学会
  • Place of Presentation: キッセイ文化ホール（長野県・松本市）
  • Year and Date: 2016-10-27
• [Presentation] シトルリン化ビメンチンは破骨細胞分化を促進する (2016)
  • Author(s): 進藤智、池田淳史、細川義隆、細川育子、尾崎和美、松尾敬志
  • Organizer: 日本歯科保存学会2016年度秋季保存学会
  • Place of Presentation: キッセイ文化ホール（長野県・松本市））
  • Year and Date: 2016-10-27
• [Presentation] Alkanninはヒト歯根膜由来細胞のCCR5 ligand産生を抑制する (2015)
  • Author(s): 細川 義隆、細川 育子、進藤 智、尾崎 和美、松尾 敬志
  • Organizer: 第１４３回秋季歯科保存学会学術大会
  • Place of Presentation: 文京シビックホール（東京都文京区）
  • Year and Date: 2015-11-12
• [Presentation] IL-4がヒト歯根膜由来細胞のCCL11およびCCL20産生に及ぼす影響 (2015)
  • Author(s): 細川 義隆、細川 育子、進藤 智、尾崎 和美、松尾 敬志
  • Organizer: 第５８回秋季日本歯周病学会学術大会
  • Place of Presentation: アクトシティ浜松（静岡県浜松市）
  • Year and Date: 2015-09-12