• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Prevention of oral cancer and pathogenesis of stomatitis during chemo-radiotherapy via the control of oxidative stress

Research Project

Project/Area Number 15K11418
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Social dentistry
Research InstitutionThe University of Tokushima

Principal Investigator

TAMAKI Naofumi  徳島大学, 大学院医歯薬学研究部(歯学系), 准教授 (20335615)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords酸化ストレス / 抗酸化力 / 抗酸化物質 / 炎症性サイトカイン / 口内炎
Outline of Final Research Achievements

In the drinking hydrogen-rich water as an antioxidant, the palatal wound healing process was accelerated compared to that in the control group. As molecular hydrogen upregulated the Nrf2, systemic oxidative stresses were decreased by the activation of antioxidant activity. Furthermore, hydrogen-rich water intake reduced proinflammatory cytokine levels and promoted the expression of healing-associated factors. Oral administration of hydrogen-rich water would be beneficial during the wound healing process.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (6 results)

All 2017 2016 2015 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Invited: 1 results) Remarks (2 results)

  • [Journal Article] Hydrogen-rich water intake accelerates oral palatal wound healing via activation of the Nrf2/antioxidant defense pathways in a rat model2016

    • Author(s)
      Tamaki N, Orihuela R, Fukui M, Ito H-O
    • Journal Title

      Oxidative Medicine and Cellular Longevity

      Volume: 2016 Issue: 1 Pages: 5679040-5679040

    • DOI

      10.1155/2016/5679040

    • NAID

      120005775421

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 実験的口腔粘膜炎モデルにおけるレスベラトロールの効果の検討2017

    • Author(s)
      玉木直文,Rita Orihuela-Campos,陳 舒,福井 誠,伊藤博夫
    • Organizer
      第66回 日本口腔衛生学会総会
    • Related Report
      2017 Annual Research Report 2016 Research-status Report
  • [Presentation] 地域住民における歯周病と酸化ストレスの関連性の検討2016

    • Author(s)
      玉木直文
    • Organizer
      第65回 日本口腔衛生学会総会
    • Place of Presentation
      東京医科歯科大学(東京都・文京区)
    • Year and Date
      2016-05-27
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 水素水の抗酸化・抗炎症作用の検討2015

    • Author(s)
      玉木直文,Rita Orihuela-Campos,福井 誠,三木かなめ,伊藤博夫
    • Organizer
      第64回 日本口腔衛生学会総会
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2015-05-27
    • Related Report
      2015 Research-status Report
  • [Remarks]

    • URL

      http://pub2.db.tokushima-u.ac.jp/ERD/person/246751/work-ja.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 徳島大学大学院医歯薬学研究部予防歯学分野

    • URL

      http://preventdent-tokushima-u.jp/index.html

    • Related Report
      2016 Research-status Report 2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi