| Project/Area Number |
15K12340
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MIYAMOTO Kenichi 徳島大学, 大学院医歯薬学研究部(医学系), 教授 (70174208)
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| Co-Investigator(Kenkyū-buntansha) |
瀬川 博子 徳島大学, 大学院医歯薬学研究部(医学系), 講師 (70325257)
辰巳 佐和子 徳島大学, 大学院医歯薬学研究部(医学系), 助教 (80420545)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | リン / 寿命 / 腎臓 / 食事 / klotho / 糖鎖 / 亜鉛 / ミトコンドリア / Klotho |
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| Outline of Final Research Achievements |
Dietary modifications such as calorie restrictions have a lifespan extension effect. Klotho deficient (KL) mice are short-lived, aged-promoted model mice. The inorganic phosphate (Pi) -restricted diet prolongs the life span of KL mice and restores its phenotype. In this study, we investigated whether Pi-restricted diet causes the modification of the N-glycosylation of Npt2c. By Pi-restricted diet, Npt2c and Klotho were induced, and the N-glycosylation pattern of Npt 2c was changed. KLNpt2c (Klotho/Npt2c DKO) mice showed the rescued KL phenotypes. In conclusion, Pi restriction was considered to be a diet inducing N-glycan modification
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