Development of novel therapeutics for the preventions of cervical cancer

• Project/Area Number: 15K12518
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Kyoto Prefectural University
• Principal Investigator: Tsukamoto Yasuhiro 京都府立大学, 生命環境科学研究科, 教授 (90305657)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 子宮頸がん / 抗体 / HPV / ダチョウ / ダチョウ抗体 / 子宮頸癌 / ＨＰＶ

Outline of Final Research Achievements

In the present study, we have developed ostrich IgY against HPV proteins. The IgY could bind specifically to HPV proteins and neutralize the viral infections to culture cells even in the lower dosages. These results suggested that IgY against HPV proteins blocked the viral adsorptions onto cell cell surface of culture cells and inhibited the viral infections. The IgY might have a potential to inhibit and prevention of HPV infections in humans by applying in love lotions etc, leading to prevention of cervical cancers. We need further in vivo and clinical studies to clarify this point.

Research Products

• [Int'l Joint Research] ハーバード大学医学部(米国)