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New combination therapy against solid tumor.

Research Project

Project/Area Number 15K12523
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionJikei University School of Medicine

Principal Investigator

Masayuki Yokoyama  東京慈恵会医科大学, 医学部, 教授 (20220577)

Co-Investigator(Renkei-kenkyūsha) SHIRAISHI Koichi  東京慈恵会医科大学, 医学部, 准教授 (40426284)
KONDO Takashi  富山大学, 大学院医学薬学部, 教授 (40143937)
AOKI Manabu  東京慈恵会医科大学, 医学部, 教授 (90246364)
SUGITA Yoichi  東京慈恵会医科大学, 医学部, 非常勤講師 (40130174)
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords超音波照射 / 固形がん / 超音波強度 / 生体透過率 / 超音波変調 / がん併用療法 / X線照射 / 一酸化窒素 / ラジオセンシタイザー
Outline of Final Research Achievements

Transmittance of ultrasound intensity through living body is the most important factor for safe and effective therapies by the use of ultrasound. We found substantial fluctuation in the transmittance due to interference phenomena of ultrasound. We obtained good agreements of the fluctuation between theoretical calculation and experimental measurements both with a phantom model and human samples. Furthermore, this fluctuation was successfully reduced by the use of modulated ultrasound. These findings can greatly contribute to advances of safe and effective ultrasound therapies.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2017 2016 2015

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Invited: 2 results)

  • [Journal Article] An Uncovered Risk Factor of Sonothrombolysis: Substantial Fluctuation of Ultrasound Transmittance through the Human Skull.2017

    • Author(s)
      Zuojun Wang, Teppei Komatsu, Hidetaka Mitsumura, Norio Nakata, Takeki Ogawa, Yasuyuki Iguchi, Masayuki Yokoyama
    • Journal Title

      Ultrasonics

      Volume: 77 Pages: 168-175

    • DOI

      10.1016/j.ultras.2017.02.012

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Exploring the relationship between Anti-PEG IgM behaviors and PEGylated nanoparticles and its significance for accelerated blood clearance2016

    • Author(s)
      Kouichi Shiraishi, Kumi Kawano, Yoshie Maitani, Taiki Aoshi, Ken J. Ishii Yusuke Sanada, Shinichi Mochizuki, Kazuo Sakurai, Masayuki Yokoyama
    • Journal Title

      J. Controlled Release

      Volume: 206 Pages: 1-15

    • DOI

      10.1016/j.jconrel.2016.05.010

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Substantial fluctuation of acoustic intensity transmittance through a bone-phantom plate and its equalization by modulation of ultrasound frequency2015

    • Author(s)
      Osamu Saito, Zuojun Wang, Hidetaka Mitsumura, Takeki Ogawa, Yasuyuki Iguchi, Masayuki Yokoyama
    • Journal Title

      Ultrasonics

      Volume: 59 Pages: 94-101

    • DOI

      10.1016/j.ultras.2015.01.017

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Determination of polymeric micelles’' structural characteristics, and effect of the characteristics on pharmacokinetic behaviors2015

    • Author(s)
      Kouichi Shiraishi, Yusuke Sanada, Shin-ichi Mochizuki, Kumi Kawano, Yoshie Maitani, Kazuo Sakurai and Masayuki Yokoyama
    • Journal Title

      J. Controlled Release

      Volume: 203 Pages: 77-84

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] 500kHz周辺中周波数超音波のヒト頭蓋骨における透過率変動とその抑制法2015

    • Author(s)
      横山昌幸、王作軍、斎藤理、小松鉄平、三村秀毅、井口保之、小川武希、中田典生
    • Organizer
      第14回日本超音波治療研究会
    • Place of Presentation
      高知
    • Year and Date
      2015-11-27
    • Related Report
      2015 Research-status Report
  • [Presentation] DDSを用いた脳梗塞診断2015

    • Author(s)
      横山昌幸、王作軍、白石貢一
    • Organizer
      第31回日本DDS学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-07-02
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 薬物超音波併用次世代普及型低侵襲治療装置の開発から得た新たな知見2015

    • Author(s)
      横山昌幸,齋藤理,王作軍,小川武希,小松鉄平,三村秀毅,井口保之
    • Organizer
      第34回日本脳神経超音波学会総会
    • Place of Presentation
      京都
    • Year and Date
      2015-06-05
    • Related Report
      2015 Research-status Report
    • Invited

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Published: 2015-04-16   Modified: 2018-03-22  

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