Depicting neural circuit that evokes cataplexy
Project/Area Number |
15K12768
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Basic / Social brain science
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Research Institution | University of Tsukuba (2016) Kanazawa University (2015) |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | ナルコレプシー / オレキシン / 視床下部 / 睡眠障害 / カタプレキシー / 情動 |
Outline of Final Research Achievements |
We identified several brain regions that are implicated in the emergence of cataplexy-like episodes in orexin/ataxin-3 mice, a rodent model of narcolepsy. Optogenetic excitation with specific stimulating conditions evoke cataplexy in these mice.
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Report
(3 results)
Research Products
(27 results)
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[Journal Article] Serotonin neurons of the dorsal raphe mediate the anti-cataplectic action of orexin neurons by reducing the amygdala activity2017
Author(s)
Hasegawa, E., Maejima, T., Yoshida, T., Masseck O.A., Herlitze, S., Yoshioka, M., Sakurai, T., Mieda, M.
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Journal Title
Proc Natl Acad Sci U S A.
Volume: 114
Issue: 17
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] QRFP-deficient mice are hypophagic, lean, hypoactive and exhibit increased anxiety-like behavior2016
Author(s)
Okamoto K, Yamasaki M, Takao K, Soya S, Iwasaki M, Sasaki K, Magoori K, Sakakibara I, Miyakawa T, Mieda M, Watanabe M, Sakai J, Yanagisawa M, Sakurai T
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Journal Title
PLoS ONE
Volume: 11
Issue: 11
Pages: e0164716-e0164716
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Nighttime administration of nicotine improves hepatic glucose metabolism via the hypothalamic orexin system in mice.2016
Author(s)
Tsuneki H, Nagata T, Fujita M, Kon K, Wu N, Takatsuki M, Yamaguchi K, Wada T, Nishijo H, Yanagisawa M, Sakurai T, Sasaoka T.
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Journal Title
Endocrinology
Volume: 157
Issue: 1
Pages: 195-206
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Messenger RNA expression profile of sleep-related genes in peripheral blood cells in patients with chronic kidney disease.2015
Author(s)
Kitajima S, Iwata Y, Furuichi K, Sagara A, Shinozaki Y, Toyama T, Sakai N, Shimizu M, Sakurai T, Kaneko S, Wada T.
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Journal Title
Clin Exp Nephrol
Volume: 20
Issue: 2
Pages: 218-25
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] The role of adult born neurons during sleep.2015
Author(s)
Sakaguchi, M., Kumar, D., Hayashi, M., Yu, L.M., McHugh, T.J., Sakurai, T
Organizer
The 38th Annual Meeting of the Japan Neuroscience Society.
Place of Presentation
神戸コンベンションセンター、神戸、兵庫県
Year and Date
2015-07-28
Related Report
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[Presentation] Cellular clocks in AVP neurons of the SCN are critical for interneuronal coupling regulating circadian behavior thythm.2015
Author(s)
Mieda, M., Ono, D., Hasegawa, E., Okamoto, H., Honma, K., Honma, S., Sakurai, T.
Organizer
The 38th Annual Meeting of the Japan Neuroscience Society.
Place of Presentation
神戸コンベンションセンター、神戸、兵庫県
Year and Date
2015-07-28
Related Report
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