| Project/Area Number |
15K14437
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
System genome science
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| Research Institution | Hokkaido University (2016)
Keio University (2015) |
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Principal Investigator |
Sato Masanao 北海道大学, 農学研究院, 助教 (20517693)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 種間遺伝学的相互作用 / DNAバーコード / アンプリコンシークエンシング |
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| Outline of Final Research Achievements |
Microbes and hosts have been co-evolved as they have repeatedly developed a better strategy to infect/defend in infection processes and to counter it. Such coevolution processes result in development of highly complex gene network in both host and microbes. To elucidate the gene network in host or microbe for their interaction, high throughput molecular profiling and genetic interaction analyses have identified thousands of genes in host or microbe. A major next challenge in research on host-microbe interactions is to elucidate interactions between host and microbial gene networks.
In this study, I aimed at development of a method to efficiently collect genetic information on how host and microbial gene networks interact in an seamlessly integrated manner. The developed protocol and data analysis pipeline accurately collect readouts in an inter-species genetic interactions en masse.
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