Control of phenotypic plasticity in armed hone beatle.
| Project/Area Number |
15K14443
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Molecular biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OHTA Kunihiro 東京大学, 大学院総合文化研究科, 教授 (90211789)
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| Co-Investigator(Kenkyū-buntansha) |
岡田 泰和 東京大学, 大学院総合文化研究科, 助教 (10638597)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | エピゲノム / 栄養 / 表現型可塑性 / 形態形成 / 発生 / 遺伝子発現 / 環境 |
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| Outline of Final Research Achievements |
Nutritional conditions during early development influence the plastic expression of adult phenotypes. Because heightened nutrition sensitivity often characterizes the development of exaggerated traits, there should be molecular mechanisms underlying trait-specific variability. This study reveals the molecular mechanisms underlying the expression of nutrition-sensitive mandibles in the beetle Gnatocerus cornutus. We found that epigenetic regulators, such as histone deacetylases (HDACs) and polycomb group (PcG) proteins, contribute specifically to the plastic expression of male mandibles, with little contribution to other body modules. In addition, HDAC1 and HDAC3 perturbation resulted in opposite phenotypic effects on mandible and wing modules. Our findings provide molecular evidence of a link between distinct epigenetic modifications and module-specific phenotypic plasticity of exaggerated traits.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing.2016
Author(s)
Tashiro S, Handa T, Matsuda A, Ban T, Takigawa T, Miyasato K, Ishii K, Kugou K, Ohta K, Hiraoka Y, Masukata H, Kanoh J.
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Journal Title
Nature Commun.
Volume: 7
Issue: 1
Pages: 10393-10393
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Glycerophospholipid regulation of modality-specific sensory axon guidance in the spinal cord.2015
Author(s)
Guy AT, Nagatsuka Y, Ooashi N, Inoue M, Nakata A, Greimel P, Inoue A, Nabetani T, Murayama A, Ohta K, Ito Y, Aoki J, Hirabayashi Y, Kamiguchi H
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Journal Title
Science
Volume: 349
Issue: 6251
Pages: 974-977
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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