| Project/Area Number |
15K14510
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
Koike Masaaki 奈良先端科学技術大学院大学, 研究推進機構, 特任助教 (10598402)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | バイオセンサー / 小胞体ストレス / 小胞体ストレス応答 / FRET / UPR |
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| Outline of Final Research Achievements |
The endoplasmic reticulum (ER) has important roles, such as protein synthesis, redox regulation, and calcium concentration regulation. It is known that abnormalities of these regulation occur ER stress response. In this study, we developed a new ER stress biosensor which can visualize ER stress response. By using biosensor prepared in the future, it is expected to study analysis of novel ER stress signal mechanism which has not been clarified so far.
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