| Project/Area Number |
15K14612
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Physical anthropology
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| Research Institution | The University of Tokyo (2017)
Jichi Medical University (2015-2016) |
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Principal Investigator |
Kazuhiro Nakayama 東京大学, 大学院新領域創成科学研究科, 准教授 (90433581)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | エピジェネティクス / 環境適応 / ヒト / 遊牧 / 農耕 / DNAメチル化 / モンゴル人 / タイ人 / 栄養 / 人類学 |
|---|
| Outline of Final Research Achievements |
To evaluate the influence of differences in traditional life styles on epigenetic information and phenotypic diversity, We compared the genome - wide methylation levels of the peripheral blood DNA of 48 individuals from Mongolians (nomadic pastoralists) and Thai (agriculturalist). As a result, it was revealed that the CpG sequences near the promoter of the genes contributing to energy metabolism systems, such as the AMP activated protein kinase pathways and the peroxisome proliferator-activated receptor pathways, showed a large difference in methylation level.
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