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Study on biological activity of food-derived nucleic acids in intestinal immune system

Research Project

Project/Area Number 15K14730
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Food science
Research InstitutionThe University of Tokushima

Principal Investigator

KAWAI Yoshichika  徳島大学, 大学院医歯薬学研究部(医学系), 教授 (50380027)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords核酸 / 調理 / 腸管 / 機能性 / 食品機能 / 炎症 / 免疫機能
Outline of Final Research Achievements

Foods contain nucleic acids as well as other major nutrients, whereas the contents, optimal intake, and functions have not yet been established. In this study, we investigated the development of the methods for extraction and quantitation of nucleic acids in foods. We also found that molecular weights of nucleic acids in foods decreased during cooking with heat. In addition, we found that nucleic acids derived from soybean and chicken meat induced mRNA expression of mucin 2 and claudin 4, which contribute to the berrier functions of intestinal cells. These results suggest that food-derived nucleic acids could play a protective role by inducing the barrie functions in intestine.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (4 results)

All 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results)

  • [Journal Article] Metal-catalyzed oxidation of 2-alkenals generates genotoxic 4-oxo-2-alkenals during lipid peroxidation.2016

    • Author(s)
      Nuka E, Tomono S, Ishisaka A, Kato Y, Miyoshi N, Kawai Y.
    • Journal Title

      Biosci Biotechnol Biochem.

      Volume: 80 Issue: 10 Pages: 2007-13

    • DOI

      10.1080/09168451.2016.1191334

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Presentation] アデノシン類によるマクロファージ炎症促進作用に対するポリフェノールの効果2017

    • Author(s)
      額惠理香、大西康太、寺尾純二、河合慶親
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都女子大学(京都府京都市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] アデノシン類による炎症促進機構に対するポリフェノールの作用2016

    • Author(s)
      額惠理香、寺尾純二、河合慶親
    • Organizer
      第22回フードサイエンスフォーラム学術集会
    • Place of Presentation
      ゆのごう美春閣(岡山県美作市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] アデノシン類による炎症促進機構に対するポリフェノールの作用2016

    • Author(s)
      額惠理香、寺尾純二、河合慶親
    • Organizer
      第21回日本フードファクター学会学術集会
    • Place of Presentation
      富山国際会議場(富山県富山市)
    • Related Report
      2016 Annual Research Report

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Published: 2015-04-16   Modified: 2018-03-22  

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