Development of universal antibody therapy for Ebola hemorrhagic fever
| Project/Area Number |
15K14851
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Veterinary medical science
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| Research Institution | Hokkaido University |
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Principal Investigator |
Takada Ayato 北海道大学, 人獣共通感染症リサーチセンター, 教授 (10292062)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 人獣共通感染症 / エボラウイルス / フィロウイルス / 抗体 / 治療法 |
|---|
| Outline of Final Research Achievements |
Ebolaviruses cause severe hemorrhagic fever (Ebola hemorrhagic fever) in humans and nonhuman primates. Five phylogenetically distinct species are currently known in the genus Ebolavirus and the antigenicity among these ebolavirus species is also largely different. This study attempted to establish procedures to induce neutralizing antibodies cross-reactive to all known ebolavirus species. Our data suggest the possibility that cross-reactive neutralizing antibodies can be induced more efficiently in mice immunized with virus-like particles using an immunosuppressive agent (rapamycin) or mice infected with replication competent vesicular stomatitis virus pseudotyped with ebolavirus glycoprotein than in mice immunized with virus-like particles using a standard adjuvant.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Fcγ-receptor IIa-mediated Src signaling pathway is essential for the antibody-dependent enhancement of Ebola virus infection2016
Author(s)
Furuyama W, Marzi A, Carmody AB, Maruyama J, Kuroda M, Miyamoto H, Nanbo A, Manzoor R, Yoshida R, Igarashi M, Feldmann H, Takada A
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Journal Title
PLoS Pathog.
Volume: 12
Issue: 12
Pages: e1006139-e1006139
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Discovery of an antibody for pan-ebolavirus therapy2016
Author(s)
Furuyama D, Marzi A, Nanbo A, Haddock E, Maruyama J, Miyamoto H, Igarashi M, Yoshida R, Dr. Noyori O, Feldmann H, Takada A
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Journal Title
Sci Rep
Volume: 6
Issue: 1
Pages: 20514-20514
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Generation of a cross-neutralizing monoclonal antibody against all known ebolavirus species/全てのエボラウイルス種に対する交差中和モノクローナル抗体の作出2016
Author(s)
Wakako Furuyama, Andrea Marzi, Asuka Nanbo, Elaine Haddock, Junki Maruyama, Hiroko Miyamoto, Manabu Igarashi, Reiko Yoshida, Osamu Noyori, Heinz Feldmann, Ayato Takada
Organizer
第64回日本ウイルス学会学術集会
Place of Presentation
札幌コンベンションセンター（札幌市、日本）
Year and Date
2016-10-23
Related Report
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[Presentation] エボラウイルスとは2015
Author(s)
高田礼人
Organizer
第15回日本ハ-イオセーフティ学会総会
Place of Presentation
戸山サンライズ（東京都新宿区、日本）
Year and Date
2015-09-15
Related Report
Invited
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[Presentation] エボラ出血熱2015
Author(s)
高田礼人
Organizer
第62回日本実験動物学会総会
Place of Presentation
京都テルサ（京都市、日本）
Year and Date
2015-05-28
Related Report
Invited
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