Control of rectal volume with Kampo formula during prostate radiotherapy: A prospective study
| Project/Area Number |
15K14970
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Natural medicines
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| Research Institution | Tottori University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | IMRT for prostate cancer / Rectal volume / Japanese herbal / Kampo / 前立腺癌強度変調放射線治療 / 直腸体積軽減 / 漢方薬内服 / 前立腺がん / 強度変調放射線治療 / 大建中湯 / IMRT / DKT / 放射線 / 放射線治療 |
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| Outline of Final Research Achievements |
During intensity-modulated radiation therapy (IMRT) for prostate cancer, volume and position of the rectum should be kept stable to minimize adverse events such as radiation proctitis or rectal bleeding. For this purpose, keeping the rectal volume small is essential. The purpose of this study was to investigate the effect of Daikenchuto (DKT), a traditional Japanese herbal (Kampo) on rectal volume during prostate IMRT prospectively. We divided total of 1,170 KV-CT of consecutive 30 non-metastatic prostate cancer patients into two groups. 15 patients were taken orally DKT (DKT group) and the others were not administered DKT (non-DKT group). Calculated rectal volumes of the DKT group were compared to those of the non-DKT group. Rectal volumes of DKT were smaller than that of non-DKT groups significantly. DKT appears to be useful in reducing rectal volume and intra-fractional volume variance which would help prevent radiation proctitis or rectal bleeding in prostate curative radiotherapy.
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Report
(4 results)
Research Products
(5 results)
