Study on Toxoplasma-derived brain manipulator which controls central nervous system of hosts
| Project/Area Number |
15K15118
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Parasitology (including sanitary zoology)
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| Research Institution | Obihiro University of Agriculture and Veterinary Medicine |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MUROI Yoshikage 帯広畜産大学, 畜産学部, 准教授 (80552760)
SUZUKI Yutaka 東京大学, 新領域創成科学研究科, 教授 (40323646)
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| Research Collaborator |
MAHMOUD Motamed
IHARA Fumiaki
NISHIMURA Maki
FURUOKA Hidefumi
FEREIG Ragab
UMEDA Kousuke
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 感染症 / 中枢神経系 / 免疫 / トキソプラズマ / トランスクリプトーム |
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| Outline of Final Research Achievements |
Toxoplasma gondii infects approximately one-third of the human population. T. gondii infection is a risk factor for developing mental diseases and nervous diseases. However, the mechanism(s) underlying the behavioral changes and onset of nervous diseases induced by T. gondii infection remains unclear. Therefore, this study aimed at elucidation of Toxoplasma-derived brain manipulator which controls host central nervous system. We identified TgGRAI as parasite molecule affecting host signal for brain function. TgGRAI activated NFkB signal. Furthermore,experiments of mouse behavior using TgGRAI-deficient parasite suggested that TgGRAI was involved in fear memory consolidation. Our results indicated the presence of parasite molecule for manipulation of host brain function.
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Report
(3 results)
Research Products
(31 results)
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[Journal Article] Toxoplasma gondii Infection in Mice Impairs Long-Term Fear Memory Consolidation Through Dysfunction of the Cortex and Amygdala2016
Author(s)
Ihara, F., Nishimura, M., Muroi, Y., Mahmoud, M.E., Yokoyama, N., Nagamune, K., Nishikawa, Y.
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Journal Title
Infect Immun.
Volume: 84
Issue: 10
Pages: 2861-2871
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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