Anopheline anti-platelet protein, AAPP, regulates probing time and blood feeding success in the malaria vector mosquito, Anopheles stephensi
Project/Area Number |
15K15121
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Parasitology (including sanitary zoology)
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Research Institution | Kanazawa University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
伊従 光洋 金沢大学, 薬学系, 准教授 (20608351)
都野 展子 金沢大学, 自然システム学系, 准教授 (60295102)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | マラリア / ハマダラカ / 唾液タンパク質 / ワクチン / 唾液 |
Outline of Final Research Achievements |
People living in a malaria endemic area cannot induce either protective immunity against malaria infection or inhibitory immunity against mosquito behavior following mosquito blood feeding. We hypothesize that (1) allergens containing saliva components disrupt and/or weaken host immune system, (2) functional domains of saliva proteins are hidden from host immune attack, resulting in induction of antibodies to non-functional domains of those proteins. We aim to develop a new concept malaria vaccine based on the hypothesis. The vaccine consisting of mosquito saliva proteins will overcome those allergy and decoy.
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Report
(3 results)
Research Products
(11 results)
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[Presentation] Plasmodium falciparum CSP vaccine based on a heterologous adenoviru-sprime and baculovirus-boost immunization regimen confers sterile protection against transgenic P.berghei sporozoite challenge2017
Author(s)
Kunitaka Yoshida, Mitsuhiro Iyori, Ahmed M. Salman, Pawan Dulal, Shahid M. Khan, Chris J. Janse, Sumi Biswas, Masaharu Tokoro, Andrew M. Blagborough, Adrian V.S. Hill, Shigeto Yoshida
Organizer
The U.S.‐Japan Cooperative Medical Sciences Program Presents the 19th International Conference on Emerging Infectious Diseases (EID)
Place of Presentation
韓国 ソウル
Year and Date
2017-02-07
Related Report
Int'l Joint Research
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[Presentation] Enhanced protective efficacy of a P. falciparum malaria vaccine using a heterologous prime-boost immunization with a baculoviral vaccine and ChAd63 expressing PfCSP against challenge with a transgenic P. berghei sporozoites2016
Author(s)
Kunitaka Yoshida, Ahmed M. Salman, Pawan Dulal, Shahid M. Khan, Chris J. Janse, Sumi Biswas, Masaharu Tokoro, Mitsuhiro Iyori, Andrew M. Blagborough, Adrian V. S. Hill, Shigeto Yoshida
Organizer
ASTMH 65th Annual Meeting
Place of Presentation
アメリカ アトランタ
Year and Date
2016-11-13
Related Report
Int'l Joint Research
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[Presentation] Vectored PfCSP Vaccines based on Baculovirus Dual Expression System and AdHu5 induce Strong Protective Efficacy against Transgenic Plasmodium berghei2016
Author(s)
Mitsuhiro Iyori, Andrew M. Blagborough, Sota Ogata, Hidesato Nishiura, Miako Sakaguchi, Masanori Mizutani, Takahiko Tamura, Kento Genshi, Satoshi Shimada, Daisuke S. Yamamoto, Hiroyuki Matsuoka and Shigeto Yoshida
Organizer
65th ASTMH
Place of Presentation
アメリカ アトランタ
Year and Date
2016-11-13
Related Report
Int'l Joint Research
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[Presentation] A hybrid Plasmodium falciparum malaria vaccine based on adenovirus-prime and baculovirus-boost immunization regimen2016
Author(s)
Kunitaka Yoshida, Mitsuhiro Iyori, Ahmed M. Salman, Pawan Dulal, Shahid M. Khan, Chris J. Janse, Sumi Biswas, Masaharu Tokoro, Andrew M. Blagborough, Adrian V.S. Hill, Shigeto Yoshida
Organizer
第57回日本熱帯医学会大会
Place of Presentation
一橋大学
Year and Date
2016-11-05
Related Report
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[Presentation] アデノウイルスベクターとバキュロウイルスベクターを用いた新規ワクチンプラットフォームによる熱帯熱マラリアワクチンの開発2016
Author(s)
吉田邦嵩, Ahmed M. Salman, Pawan Dulal, Shahid M. Khan, Chris J. Janse, Sumi Biswas, 所正治, 伊従光洋, Andrew M. Blagborough, Adrian V.S. Hill, 吉田栄人
Organizer
第72回日本寄生虫学会西日本支部大会
Place of Presentation
岐阜大学
Year and Date
2016-10-15
Related Report
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[Presentation] A hybrid Plasmodium falciparum malaria vaccine based on adenovirus-prime and baculovirus-boost immunization regimen.2016
Author(s)
Kunitaka Yoshida, Ahmed M. Salman, Pawan Dulal, Shahid M. Khan, Chris J. Janse, Sumi Biswas, Masaharu Tokoro, Mitsuhiro Iyori, Andrew M. Blagborough, Adrian V. S. Hill, Shigeto Yoshida
Organizer
第14回松山国際学術シンポジウム
Place of Presentation
愛媛大学
Year and Date
2016-09-15
Related Report
Int'l Joint Research
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