| Project/Area Number |
15K15155
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Ehime University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KUWAHARA Makoto 愛媛大学, 大学院医学系研究科, 助教 (00568214)
SUZUKI Junpei 愛媛大学, 大学院医学系研究科, 助教(特定教員)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | グルタミン代謝 / ヘルパーT細胞 / エピゲノム / サイトカイン / Th2 / 免疫 / アレルギー・ぜんそく / 炎症 |
|---|
| Outline of Final Research Achievements |
After receiving antigenic stimulation, the reprogram of metabolic pathway is induced in CD4 T cells and supports rapid clonal expansion. However, the role of metabolic reprograming in the differentiation of helper T cell (Th) subset remains to be elucidated. In this study, we focused on the role of glutamine metabolism in activated CD4 T cells. We found that glutamine metabolism controls chromatin status at the cytokine gene loci and regulates Th differentiation in part via supplementation of apha-ketoglutarate.
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