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A study on the neural mechanisms of illegal drugs

Research Project

Project/Area Number 15K15182
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Applied pharmacology
Research InstitutionKyoto University

Principal Investigator

KANEKO SHUJI  京都大学, 薬学研究科, 教授 (60177516)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords薬物依存 / 薬剤感受性
Outline of Final Research Achievements

5F-ADB is the most potent synthetic cannabinoids and elicits severe psychotic symptoms in humans, sometimes causing death. To investigate the neuronal mechanisms underlying its toxicity, we examined the effects of 5F-ADB on midbrain dopaminergic and serotonergic systems, which modulate various basic brain functions such as those in reward-related behavior. 5F-ADB-induced changes in spontaneous firing activity of dopaminergic and serotonergic neurons were recorded by ex vivo electrophysiological techniques. In dopaminergic neurons, 5F-ADB (1 μM) significantly increased the spontaneous firing rate, while the same concentration of 5F-ADB failed to activate dopaminergic neurons in the presence of the CB1 antagonist AM251 (1 μM). However, 5F-ADB did not affect serotonergic-neuron activity. These results suggest that 5F-ADB activates local CB1 receptors and potentiates midbrain dopaminergic systems with no direct effects on midbrain serotonergic systems.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (2 results)

All 2016

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results) Presentation (1 results)

  • [Journal Article] A new designer drug 5F-ADB activates midbrain dopaminergic neurons but not serotonergic neurons2016

    • Author(s)
      Asaoka N, Kawai H, Nishitani N, Kinoshita H, Shibui N, Nagayasu K, Shirakawa H, Kaneko S
    • Journal Title

      The Journal of Toxicological Sciences

      Volume: 41 Issue: 6 Pages: 813-816

    • DOI

      10.2131/jts.41.813

    • NAID

      130005281915

    • ISSN
      0388-1350, 1880-3989
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 危険ドラッグ5F-ADBのドパミン・セロトニン神経活動に対する作用2016

    • Author(s)
      浅岡希美
    • Organizer
      第130回日本薬理学会近畿部会
    • Place of Presentation
      京都大学百周年時計台記念館(京都府京都市)
    • Related Report
      2016 Annual Research Report

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Published: 2015-04-16   Modified: 2018-03-22  

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