| Project/Area Number |
15K15262
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Legal medicine
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| Research Institution | Nagasaki University |
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Principal Investigator |
NAKAHARA Aya 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (80719005)
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| Co-Investigator(Kenkyū-buntansha) |
山本 琢磨 長崎大学, 医歯薬学総合研究科(医学系), 講師 (50634458)
梅原 敬弘 長崎大学, 医歯薬学総合研究科(医学系), 助教 (60617421)
池松 和哉 長崎大学, 医歯薬学総合研究科(医学系), 教授 (80332857)
坪井 貴司 東京大学, 大学院総合文化研究科, 准教授 (80415231)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 多能性幹細胞 / 法医剖検症例 / レノックス・ガストー症候群 / iPS / マウス / ヒト / 死後 / 次世代シークエンス / 人工多能性幹細胞 |
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| Outline of Final Research Achievements |
In forensic practice, it is very difficult to diagnose the cause of death such as fatal arrhythmia and metabolic disease. induced pluripotent stem (iPS) cells from fibloblast can differentiate cardiomyo-cell and hepatocyte. This means that forensic pathologist easily diagnose functional disease to check electrogram of cardiocyte and evaluate hepatocyte function. In this study, we made iPS cells from an case of Lennox-Gastaut syndrome. Actually, we collected skin tissue and cultured fibroblast from it. After culturing, iPS cells were developed. In future, we will check pluripotent of the cells and will differentiate cardiomyo-cell and hepatocyte.
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