Mucosal immune regulation by autophagy in intestinal epithelia
Project/Area Number |
15K15288
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Gastroenterology
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
NAGAISHI TAKASHI 東京医科歯科大学, 医学部附属病院, 助教 (60447464)
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Co-Investigator(Kenkyū-buntansha) |
渡辺 守 (渡邉 守) 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (10175127)
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Research Collaborator |
YAMAZAKI Motomi
ONIZAWA Michio
SUZUKI Masahiro
WATABE Taro
HOSOYA Akinori
TSUGAWA Naoya
JOSE Nisha
KOJIMA Yudai
TOKAI Arisa
TSUGE Naoto
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 炎症性腸疾患 / 粘膜免疫 / オートファジー |
Outline of Final Research Achievements |
IBD is characterized by unrestrained lymphocyte activation that results in the production of a variety of pro-inflammatory cytokines and other mediators.Understanding the mechanisms of lymphocyte regulation is therefore of significant importance to dysregulated mucosal inflammation such as IBD.On the other hand, genome-wide association studies in the analysis of IBD have identified genetic risk foci.Especially, several studies have revealed the important roles of autophagy-related genes in IBD, including the suppression of inflammasome in hematopoietic cells and secretion of antimicrobial peptides in Paneth cells.In this regards, we have observed that a lack of autophagy function led to the up-regulated pro-inflammatory cytokines in vivo.Defining the mechanisms of autophagy-mediated T cell regulation will lead to a significant understanding of the manner in which manipulation of this function may provide insights into novel therapeutic methods for the treatment of IBD.
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Report
(3 results)
Research Products
(27 results)
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[Journal Article] HADHA, the alpha subunit of the mitochondrial trifunctional protein,is involved in long-chain fatty acid-induced autophagy in intestinal epithelial cells.2017
Author(s)
Maeyashiki C, Oshima S, Otsubo K, Kobayashi M, Nibe Y, Matsuzawa Y, Onizawa M, Nemoto Y, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Watanabe M
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Journal Title
Biochem Biophys Res Commun.
Volume: 484
Issue: 3
Pages: 636-641
DOI
Related Report
Peer Reviewed
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[Journal Article] The ubiquitin hybrid gene UBA52 regulates ubiquitination of ribosome and sustains embryonic development.2016
Author(s)
Kobayashi M, Oshima S, Maeyashiki C, Nibe Y, Otsubo K, Matsuzawa Y, Memoto Y, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Watanabe M
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Journal Title
Sci. Rep.
Volume: 6
Issue: 1
Pages: 36780-36780
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy.2015
Author(s)
Matsuzawa Y, Oshima S, Takahara M, Maeyashiki C, Nemoto Y, Kobayashi M, Nibe Y, Nozaki K, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Averil Ma, Watanabe M
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Journal Title
Autophagy
Volume: 11
Issue: 7
Pages: 1052-1062
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Safety and Efficacy of AJM300, an Oral Antagonist of α4 Integrin, in Induction Therapy for Patients With Active Ulcerative Colitis.2015
Author(s)
Yoshimura N, Watanabe M, Motoya S, Tominaga K, Matsuoka K, Iwakiri R, Watanabe K, Hibi T, AJM300 Study Group
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Journal Title
Gastroenterology
Volume: 149
Issue: 7
Pages: 1775-1783
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] CEACAM1 regulation of BCR signaling in the activated B cells.2016
Author(s)
Akinori Hosoya, Takashi Nagaishi, Arisa Tokai, Taro Watabe, Nisha Jose, Yudai Kojima, Motomi Yamazaki, Richard S. Blumberg, Mamoru Watanabe.
Organizer
United European Gastroenterology Week 2016
Place of Presentation
Austria Center Vienna, Vienna (Austria)
Year and Date
2016-10-19
Related Report
Int'l Joint Research
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[Presentation] Activated B cell receptor signaling may be regulated by CEACAM1.2016
Author(s)
Arisa Tokai, Takashi Nagaishi, Taro Watabe, Nisha Jose, Akinori Hosoya, Motomi Yamazaki, Michio Onizawa, Richard S. Blumberg, Mamoru Watanabe.
Organizer
Federation of Clinical Immunology Societies 2016
Place of Presentation
Seaport Hotel & World Trade Center, Boston (U.S.A.)
Year and Date
2016-06-23
Related Report
Int'l Joint Research
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[Presentation] CD66a may regulate BCR signaling in the activated B cells.2015
Author(s)
Tokai A, Nagaishi T, Watabe T, Jose N, Yamazaki M, Onizawa M, Suzuki M, Hosoya A, Kawai Risa, Adachi T, Watanabe M
Organizer
第44回日本免疫学会学術集会
Place of Presentation
札幌コンベンションセンター (北海道札幌市)
Year and Date
2015-11-18
Related Report
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[Presentation] Epithelial TNFR2 signaling in the setting of IBD may be involved in the development of colitis-associated carcinogenesis.2015
Author(s)
Watabe T, Nagaishi T, Suzuki M, Yamazaki M, Onizawa M, Jose N, Tokai A, Hosoya A, Kawai R, Totsuka M, Watanabe M
Organizer
United European Gastroenterology Week 2015
Place of Presentation
Barcelona (Spain)
Year and Date
2015-10-24
Related Report
Int'l Joint Research
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