Signaling and Browning in White Adipose Tissues by the Receptors for Short-Chain Fatty Acids
Project/Area Number |
15K15348
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Metabolomics
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Research Institution | Kumamoto University |
Principal Investigator |
Araki Eiichi 熊本大学, 大学院生命科学研究部(医), 教授 (10253733)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | ブラウニング / 短鎖脂肪酸 / 肥満 / 内臓脂肪 / 皮下脂肪 / GPR43 / browning |
Outline of Final Research Achievements |
The induction of beige adipogenesis within white adipose tissue (WAT), known as “browning”, has received attention as a novel anti-obesity strategy. Although acetate could exhibit anti-obesity effect and induce browning of WAT in obese diabetic KK-Ay mice, the contribution of GRP43, a receptor for acetate, on acetate-induced browning, was unknown. In the present study, it was investigated whether orally administered acetate or butyrate could induce anti-obese effects, genes involved in browning, and browning of WAT in either high fat diet-fed GRP43-deficient or the control mice. In addition, the effects of acetate or butyrate on gene expression were investigated in primary-cultured adipocytes derived from WAT of GRP43-deficient or the control mice. Treatment with acetate or butyrate induced anti-obesity effect and browning of WAT in both high fat diet-fed mice and upregulated genes involved in browning in either adipocytes, suggesting the GRP43-independent mechanisms.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Identification of microRNA that represses IRS-1 expression in liver.2018
Author(s)
Ono K, Igata M, Kondo T, Kitano S, Takaki Y, Hanatani S, Sakaguchi M, Goto R, Senokuchi T, Kawashima J, Furukawa N, Motoshima H, Araki E
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Journal Title
PLoS One
Volume: 13
Issue: 1
Pages: 0191553-0191553
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Inhibition of local macrophage growth ameliorates focal inflammation and suppresses atherosclerosis.2018
Author(s)
Yamada S, Senokuchi T, Matsumura T, Morita Y, Ishii N, Fukuda K, Murakami S, Nishida S, Kawasaki S, Motoshima H, Furukawa N, Komohara Y, Fujiwara Y, Koga T, Yamagata K, Takeya M, Araki E
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Journal Title
Arteriosclerosis, Thrombosis, and Vascular Biology
Volume: 印刷中
Issue: 5
Pages: 994-1006
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Acetate alters expression of genes involved in beige adipogenesis in 3T3-L1 cells and obese KK-Ay mice2016
Author(s)
Hanatani S, Motoshima H, Takaki Y, Kawasaki S, Igata M, Matsumura T, Kondo T, Senokuchi T, Ishii N, Kawashima J, Kukidome D, Shimoda S, Nishikawa T, Araki E
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Journal Title
J Clin Biochem Nutr
Volume: 59
Pages: 207-214
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Obesity-induced microRNA-222 impairs insulin signaling through the repression of IRS-1 expression in hepatocytes.2017
Author(s)
Ono K, Igata M, Kondo T, Kitano S, Takaki Yuki, Hanatani S, Goto R, enokuchi T, Kawashima J, Furukawa N, Motoshima H, ArakiE
Organizer
The 53th EASD Annual Meeting
Related Report
Int'l Joint Research
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[Presentation] Activation of Heat Shock Response Provided by Mild Electrical Stimulation with Heat Shock Improves Metabolic Abnormalities in Obese Subjects with Type 2 Diabetes2016
Author(s)
Kondo T, Goto R, Ono K, Kitano S, Igata M, Kawashima J, Motoshima H, Matsumura T, Kai H, Araki E
Organizer
52th EASD Annual Meeting
Place of Presentation
Messe Munchen, Munich, Germany
Year and Date
2016-09-12
Related Report
Int'l Joint Research
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[Presentation] 熊本における食環境整備ブルーサークルメニュー開発の新たな展開―社員食堂版の開発―.2015
Author(s)
本島寛之, 柿村葉子, 三浦幸輔, 毛井順子, 村岡まき子, 久木留大介, 三島裕子, 前中あおい, 長瀬博美, 宮田真理子, 川島隆文, 後藤理英子, 吉村沢子, 福田伴美, 猪原淑子, 関上泰二, 白坂亜子, 岸川秀樹, 下田誠也, 荒木栄一
Organizer
第53回日本糖尿病学会九州地方会
Place of Presentation
福岡
Year and Date
2015-11-27
Related Report