Elucidation of immuno-pathogenesis of IgG4-related disease by focusing on innate immune responses to intestinal microflora
Project/Area Number |
15K15370
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Collagenous pathology/Allergology
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Research Institution | Kindai University (2016) Kyoto University (2015) |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | IgG4関連疾患 / 自己免疫性膵炎 / 形質細胞様樹状細胞 / 腸内細菌 |
Outline of Final Research Achievements |
We tried to elucidate innate immune responses involved in the development of IgG4-related autoimmune pancreatitis (AIP). To this end, we utilized samples obtained from murine experimental models of AIP and human IgG4-related AIP. In both human and animal studies, we found that AIP-related innate immune responses are characterized by activation of plasmacytoid dendritic cells (pDCs). The development of AIP depends upon both IFN-alpha and IL-33 produced by pDCs. Taken together, these data suggest that activation of pDCs upon sensing of intestinal microflora induces IgG4-related AIP through the production of IFN-alpha and IL-33.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] Chronic fibro-inflammatory responses in autoimmune pancreatitis depend on IFN-α and IL-33 produced by plasmacytoid dendritic cells2017
Author(s)
Watanabe T, YamashitaK, Arai Y, Minaga K, KamataK, Nagai T, Komeda Y, Takenaka M, Hagiwara S, Ida H, Sakurai T, Nishida N, Strober W, Kudo M
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Journal Title
Journal of Immunology
Volume: 198
Related Report
Peer Reviewed / Acknowledgement Compliant
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