Discovery of antigen-specific low affinity IgE in cord blood and the mechanisms of affinity maturation after birth for prevention of allergy
| Project/Area Number |
15K15371
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
KIDO Hiroshi 徳島大学, 先端酵素学研究所(デザイン), 特任教授 (50144978)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | アレルギー / クラススイッチ / ＩｇＥ / 湿疹 / 母乳栄養 / 人工栄養 / ＩｇＧ１ / ＩｇＧ２ / 食物アレルギー / 免疫グロブリンクラススイッチ / IgE / IgG1 / IgG2 / 予防 / 抗原親和性 / 抗原感作 |
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| Outline of Final Research Achievements |
Background and Method: Egg white (EW) and cow’s milk (CM) are major food allergens in infants. We focus on the trajectory of allergen-specific immunoglobulin subclass formations associated with immunoglobulin class switching from birth to 6 months of age. EW- and CM-specific immunoglobulin subclass levels were measured in cord blood and blood samples of infants at 2, 4 and 6 months of age by the densely carboxylated protein microarray.
Results and Conclusion: Feeding of formula containing high dose CW allergens induced high allergen-specific immunoglobulin subclass formations in the early stage. Breast feeding, which provided very low concentration of EW allergens, induced slow immunoglobulin subclass formation, but infants with eczema showed high IgE and low IgG1 at 6 month of age, with resultant high IgE/IgG1 ratio.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Two-step egg introduction for prevention of egg allergy in high-risk infants with eczema (PETIT): a randomised, double-blind, placebo-controlled trial.2017
Author(s)
Natsume O, Kabashima S, Nakazato J, Yamamoto-Hanada K, Narita M, Kondo M, Saito M, Kishino A, Takimoto T, Inoue E, Tang J, Kido H, Wong GW, Matsumoto K, Saito H, Ohya Y; PETIT Study Team..
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Journal Title
Lancet
Volume: 389
Issue: 10066
Pages: 276-286
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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