Impact of the cooperative effect of estrogen and orexin on abnormalities with emotion and metabolism in menopausal mice
| Project/Area Number |
15K15599
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | University of Toyama |
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Principal Investigator |
Sasaoka Toshiyasu 富山大学, 大学院医学薬学研究部(薬学), 教授 (00272906)
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| Co-Investigator(Kenkyū-buntansha) |
和田 努 富山大学, 大学院医学薬学研究部(薬学), 講師 (00419334)
恒枝 宏史 富山大学, 大学院医学薬学研究部(薬学), 准教授 (20332661)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | オレキシン / エストロゲン / 閉経期 / 糖代謝 / インスリン抵抗性 / 日内リズム / ストレス / うつ / 耐糖能異常 / 慢性炎症 / 脂質代謝 / 閉経 |
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| Outline of Final Research Achievements |
We examined the cooperative protective role of estrogen and orexin in abnormalities with emotion and metabolism in menopausal mice. Female, but not male mice, were protected against metabolic abnormalities fed high-fat diet. The additional orexin deficiency induced the metabolic abnormalities in the female mice. Ovariectomized orexin knockout mice fed high-fat diet presented excessive weight gain and impaired glucose tolerance. The impaired glucose tolerance was ameliorated when estrogen was administered intracerebroventricularly to the ovariectomized high-fat fed mice. However, the beneficial effect of estrogen was disappeared in the ovariectomized mice lacking orexin. These results indicate that estrogen and orexin cooperatively regulate glucose and energy homeostasis in female mice.
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Report
(3 results)
Research Products
(24 results)
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[Journal Article] Timed Inhibition of Orexin System by Suvorexant Improved Sleep and Glucose Metabolism in Type 2 Diabetic db/db Mice.2016
Author(s)
Tsuneki H, Kon K, Ito H, Yamazaki M, Takahara S, Toyooka N, Ishii Y, Sasahara M, Wada T, Yanagisawa M, Sakurai T, Sasaoka T.
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Journal Title
Endocrinology.
Volume: 157
Issue: 11
Pages: 4146-4157
DOI
Related Report
Peer Reviewed
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[Journal Article] Nighttime administration of nicotine improves hepatic glucose metabolism via the hypothalamic orexin system in mice.2016
Author(s)
Tsuneki H, Nagata T, Fujita M, Kon K, Wu N, Takatsuki M, Yamaguchi K, Wada T, Nishijo H, Yanagisawa M, Sakurai T, Sasaoka T.
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Journal Title
Endocrinology
Volume: 157
Issue: 1
Pages: 195-206
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] 糖尿病と睡眠．2016
Author(s)
笹岡利安．
Organizer
第59回日本糖尿病学会年次学術集会
Place of Presentation
京都
Year and Date
2016-05-19
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