| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Outline of Final Research Achievements |
Genomic sequencing analysis was performed in the 15 groups consisting of the survivor who had undergone the treatment for childhood cancer after 1980, its partner, and descendant. Among 6 survivors whose tumors had been advanced of stage, exome analysis revealed 2, 9, 12, 16, 32, and 84 mutations occurred after treatment, respectively. Among 4 survivors including 2 survivors with secondary malignancy, whole genome sequencing revealed 126、87、73, 198 mutations occurred after treatment. The genomic analysis of 3 descendants using exome analysis, 3 of 84, 1 of 12, and 0 of 34 mutations were suspected to be inherited, respectively. The exome analysis of 4 cases with secondary malignancies showed no common mutations nor mutation signatures.
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