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Development of ginger-containing orally disintegrating tablet with swallowing function improvement ability

Research Project

Project/Area Number 15K16189
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Eating habits
Research InstitutionKochi University

Principal Investigator

Abe Noriaki  高知大学, 医学部附属病院, 薬剤師 (00717332)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Keywords嚥下 / サブスタンスP / 唾液 / 口腔内崩壊錠 / 口腔内崩壊譲 / 嚥下機能改善剤 / 臨床試験
Outline of Final Research Achievements

In this study, we have shown the followings: (1) the amount of Substance P (SP) in saliva shows a negative correlation with age, (2) it is increased by taking ginger-containing oral disintegration (OD) tablets, (3) there is a negative correlation between functional evaluation score of swallowing by endoscopic examination and age, and (4) the swallowing score improves by taking ginger-containing OD tablets.
These results were suggested that SP in saliva may work as a clinical marker for swallowing function and ginger-containing OD tablets may improve swallowing function.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report

Research Products

(3 results)

All 2017 2016

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results)

  • [Journal Article] Ginger Orally Disintegrating Tablets to Improve Swallowing in Older People2016

    • Author(s)
      Hirata A, Funato H, Nakai M, Iizuka M, Abe N, Yagi Y, Shiraishi H, Jobu K, Yokota J, Hirose K, Hyodo M, Miyamura M.
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 39 Issue: 7 Pages: 1107-1111

    • DOI

      10.1248/bpb.b15-01045

    • NAID

      130005160768

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 口腔局所TRPV1刺激によるZingiber officinaleの嚥下機能改善効果2017

    • Author(s)
      平田歩, 石田智滉, 石田七生, 飯塚美知郎, 阿部譲朗, 八木祐助, 白石久, 常風興平, 横田淳子, 弘瀬かほり, 兵頭政光, 吉岡三郎, 宮村充彦
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター・東北大学(宮城県仙台市)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Research-status Report
  • [Presentation] ショウガ口腔内刺激型製剤投与による嚥下機能改善作用 -TRPV1およびサブスタンスPの遺伝子発現に関する検討-2016

    • Author(s)
      平田歩, 飯塚美知郎, 石田七生, 船戸裕樹, 阿部譲朗, 仲井めぐみ, 八木祐助, 白石久, 常風興平, 横田淳子, 宮村充彦
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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