Development of ginger-containing orally disintegrating tablet with swallowing function improvement ability

• Project/Area Number: 15K16189
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: Kochi University
• Principal Investigator: Abe Noriaki 高知大学, 医学部附属病院, 薬剤師 (00717332)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
• Keywords: 嚥下 / サブスタンスP / 唾液 / 口腔内崩壊錠 / 口腔内崩壊譲 / 嚥下機能改善剤 / 臨床試験

Outline of Final Research Achievements

In this study, we have shown the followings: (1) the amount of Substance P (SP) in saliva shows a negative correlation with age, (2) it is increased by taking ginger-containing oral disintegration (OD) tablets, (3) there is a negative correlation between functional evaluation score of swallowing by endoscopic examination and age, and (4) the swallowing score improves by taking ginger-containing OD tablets.
These results were suggested that SP in saliva may work as a clinical marker for swallowing function and ginger-containing OD tablets may improve swallowing function.

Research Products

• [Journal Article] Ginger Orally Disintegrating Tablets to Improve Swallowing in Older People (2016)
  • Author(s): Hirata A, Funato H, Nakai M, Iizuka M, Abe N, Yagi Y, Shiraishi H, Jobu K, Yokota J, Hirose K, Hyodo M, Miyamura M.
  • Journal Title: Biol. Pharm. Bull. Volume: 39 Issue: 7 Pages: 1107-1111
  • DOI: 10.1248/bpb.b15-01045
  • NAID: 130005160768
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] 口腔局所TRPV1刺激によるZingiber officinaleの嚥下機能改善効果 (2017)
  • Author(s): 平田歩, 石田智滉, 石田七生, 飯塚美知郎, 阿部譲朗, 八木祐助, 白石久, 常風興平, 横田淳子, 弘瀬かほり, 兵頭政光, 吉岡三郎, 宮村充彦
  • Organizer: 日本薬学会第137年会
  • Place of Presentation: 仙台国際センター・東北大学(宮城県仙台市)
  • Year and Date: 2017-03-24
• [Presentation] ショウガ口腔内刺激型製剤投与による嚥下機能改善作用 -TRPV1およびサブスタンスPの遺伝子発現に関する検討- (2016)
  • Author(s): 平田歩, 飯塚美知郎, 石田七生, 船戸裕樹, 阿部譲朗, 仲井めぐみ, 八木祐助, 白石久, 常風興平, 横田淳子, 宮村充彦
  • Organizer: 日本薬学会第136年会
  • Place of Presentation: パシフィコ横浜（横浜）
  • Year and Date: 2016-03-26