| Project/Area Number |
15K16567
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Basic / Social brain science
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | フッ素 / 記憶学習能力 / 行動試験 / ＩＱ / Ｂａｒｎｅｓ ｍａｚｅ / Ｙ-maze / 神経毒性 / 妊娠期曝露 / バーンズ迷路 / Y-maze / 高架型十字迷路 / 記憶学習 / Barnes maze / 高架式十字迷路 / 脳科学 |
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| Outline of Final Research Achievements |
Endemic fluorosis has been reported in many countries. Neurotoxic effects of fluoride on the ability of learning and memory have been focused lately. In this study, we evaluated the neurotoxic effects of fluoride on the learning ability of mice at low doses in the drinking water. Pregnant ICR mice were administered fluoride in the drinking water 0, 5, 25 or 50 ppm. After weaning, the female and male F1 mice were also administered fluoride in the drinking water 0, 5, 25 or 50 ppm until 6-months of age. The mean number of entries without repetition in the 5, 25 or 50 ppm group was significantly level than that in the control at the Y-maze test. The mean time spent in the escape box in the 5, 25 or 50 ppm group was significantly lower than that in the control at the Barnes maze. From the results of the Y-maze test and the Barnes maze, it was demonstrated that the exposure to fluoride drinking during stage from fetus and development induced cognitive deficit.
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