The epigenetics-driven adaptive evolution concept and its application to microbe engineering
Project/Area Number |
15K18665
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Applied microbiology
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Research Institution | University of Tsukuba (2016-2017) The University of Tokyo (2015) |
Principal Investigator |
Yano Hirokazu 筑波大学, 生命環境系, 研究員 (20646773)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | ゲノム / ピロリ菌 / メチローム / トランスクリプトーム / 制限修飾系 / エピゲノム |
Outline of Final Research Achievements |
We revealed the functionality of diverse methyltransferase genes in the pathogen (H. pylori) genome. We established experimental and analytical protocols for bacterial methylome and transcriptome studies. We discovered an epigenetic network consisting of multiple regulatory networks governed by site-specific DNA methyltransferases. We discovered a novel restriction-modification system potentially useful for epigenome engineering.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Restriction glycosylases: involvement of endonuclease activities in the restriction process.2017
Author(s)
Ming-Zhang Xie, Tomoyuki Matsuzaka, Hirokazu Yano, Yoshikazu Furuta, Toshiaki Nakano, Ken Ishikawa, Masaki Fukuyo, Noriko Takahashi, Yutaka Suzuki, Sumio Sugano, Hiroshi Ide and Ichizo Kobayashi
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Journal Title
Nucleic Acids Res
Volume: 45
Pages: 1392-1403
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Population structure and local adaptation of MAC lung disease agent Mycobacterium avium subsp. hominissuis2018
Author(s)
Hirokazu Yano, Tomotada Iwamoto, Yukiko Nishiuchi, Chie Nakajima, Daria A. Starkova, Igor Mokrousov, Olga Narvskaya, Shiomi Yoshida, Kentaro Arikawa, Noriko Nakanishi, Ken Osaki, Ichiro Nakagawa, Manabu Ato, Yasuhiko Suzuki, and Fumito Maruyama
Organizer
日本進化学会 京都大学吉田キャンパス 2017年8月24-26日
Related Report
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[Presentation] Population structure and local adaptation of MAC lung disease agent Mycobacterium avium subsp. hominissuis2018
Author(s)
Hirokazu Yano, Tomotada Iwamoto, Yukiko Nishiuchi, Chie Nakajima, Daria A. Starkova, Igor Mokrousov, Olga Narvskaya, Shiomi Yoshida, Kentaro Arikawa, Noriko Nakanishi, Ken Osaki, Ichiro Nakagawa, Manabu Ato, Yasuhiko Suzuki, and Fumito Maruyama
Organizer
The 52nd US-Japan Mycobacteria Panel Meeting 2018 in Niigata, Japan, March 15-16, 2018
Related Report
Int'l Joint Research
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[Presentation] Network of DNA methyltransferase behind the adaptive phenotype in Helicobacteri pylori2015
Author(s)
Hirokazu Yano, Zobaidul M. Alam, Emiko Rimbara, Yoshikazu Furuta, Yutaka Suzuki, Sumio Sugano, Keigo Shibayama, Ichizo Kobayashi
Organizer
Gordon Research Conference, Microbial Population Biology
Place of Presentation
Andover, NH, USA
Year and Date
2015-07-19
Related Report
Int'l Joint Research
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