Development of selective antagonist of COI1-JAZ receptor
Project/Area Number |
15K18687
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Bioorganic chemistry
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Research Institution | Tohoku University |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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Keywords | アゴニスト / 植物ホルモン / コロナチン / 生理活性 / 植物 |
Outline of Final Research Achievements |
In this study, JAZ subtype-selective agonists, which selectively activate useful functions among diverse physiological roles by jasmonic acids signaling, are developed based on coronatine which is a mimic of jasmonoyl-L-isoleucine with potent activities. A lead compound used for JAZ selective agonist development was found using an evaluation system of pull-down assay system COI1-JAZ interaction using JAZ fragment peptide which is a binding domain with COI1 of JAZ. Based on the knowledge, we designed several compounds that are thought to be more selective improvement by in silico docking study. By a similar pull-down assay, two subtype-selective agonists that bind to some of JAZ were found among them.
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Report
(3 results)
Research Products
(39 results)
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[Journal Article] GTR1 is a jasmonic acid and jasmonoyl-l-isoleucine transporter in Arabidopsis thaliana.2017
Author(s)
Ishimaru, Y., Oikawa, T., Suzuki, T., Takeishi, S., Matsuura, H., Takahashi, K., Hamamoto, S., Uozumi, N., Shimizu, T., Seo, M., Ohta, H., and Ueda, M.
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Journal Title
Bioscience, Biotechnology, and Biochemistry
Volume: 81
Issue: 2
Pages: 249-255
DOI
Related Report
Peer Reviewed
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[Journal Article] Jasmonate signaling is activated in the very early stages of iron deficiency responses in rice roots.2016
Author(s)
Kobayashi, T. (corresponding author), Itai, R.N., Senoura, T., Oikawa, T., Ishimaru, Y., Ueda, M., Nakanishi, H., Nishizawa, N.K.
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Journal Title
Plant Molecular Biology
Volume: 印刷中
Issue: 4-5
Pages: 533-547
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] The jasmonate-responsive GTR1 transporter is required for gibberellin-mediated stamen development in Arabidopsis2015
Author(s)
H. Saito, T. Oikawa, S. Hamamoto, Y. Ishimaru, T. Utsumi, J. Chen, M. Kanamori, Y. Sasaki-Sekimoto, M. Shimojima, S. Masuda, Y. Kamiya, M. Seo, N. Uozumi, M. Ueda, H. Ohta, A
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Journal Title
Nature Communications
Volume: 6
Issue: 1
Pages: 6095-6095
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Elevated levels of CYP94 family gene expression alleviate the jasmonate response and enhance salt tolerance in rice2015
Author(s)
Kurotani, K., Hayashi, K., Hatanaka, S., Toda, Y., Ogawa, D., Ichikawa, H., Ishimaru, Y., Tashita, R., Suzuki, T., Ueda, M., Hattori, T. and Takeda S.
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Journal Title
Plant Cell Physiol.
Volume: 56
Issue: 4
Pages: 779-789
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Iron deficiency regulated OsOPT7 is essential for iron homeostasis in rice2015
Author(s)
K. Bashir, Y. Ishimaru, R. Nakanishi Itai, T. Senoura, M. Takahashi, G. An, T. Oikawa, M. Ueda, A. Sato, N. Uozumi, H. Nakanishi, and N. K Nishizawa
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Journal Title
Plant Mol. Biol.
Volume: 88
Issue: 1-2
Pages: 165-176
DOI
Related Report
Peer Reviewed
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