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Basic and clinical studies on the renal effects of the alpha 2-adrenoceptor agonist

Research Project

Project/Area Number 15K18794
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Veterinary medical science
Research InstitutionTottori University

Principal Investigator

MURAHATA YUSUKE  鳥取大学, 農学部, 助教 (30734743)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsα2アドレナリン受容体 / 腎臓 / デクスメデトミジン / レミフェンタニル / セボフルラン / イヌ / α2アドレナリン受容体作動薬 / 吸入麻酔薬 / 最小肺胞内濃度
Outline of Final Research Achievements

The alpha-2 adrenoceptor agonist dexmedetomidine decreased minimum alveolar concentration of sevoflurane in a dose-dependent manner, and there was a synergistic interaction between dexmedetomidine and remifentanil in dogs.
This study revealed that the renal blood flow and glomerular filtration rate were maintained during dexmedetomidine constant rate infusion with sevoflurane-remifentanil anesthesia in dogs, in spite of the heart rate and cardiac index decreased due to the increase of the systemic vascular resistance index.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (2 results)

All 2017

All Presentation (2 results)

  • [Presentation] 犬におけるセボフルランの各種麻酔深度の指標に対するレミフェンタニルの効果2017

    • Author(s)
      村端悠介、日笠喜朗、林将、重松宏紀、朱夏希、柄武志、大崎智弘、岡本芳晴、今川智敬
    • Organizer
      第95回日本獣医麻酔外科学会・2017年秋季合同学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 犬におけるセボフルラン最小肺胞内濃度に対するレミフェンタニル-デクスメデトミジンの相互作用の検討2017

    • Author(s)
      朱夏希、村端悠介、日笠喜朗、岸田光、東和生、伊藤典彦、山下真路、今川智敬
    • Organizer
      第95回日本獣医麻酔外科学会・2017年秋季合同学会
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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