Development of novel asymmetric catalyst based on piperazinone derivatives

Research Project

Project/Area Number	15K18829
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Chemical pharmacy
Research Institution	The University of Tokushima
Principal Investigator	NAKAO Michiyasu 徳島大学, 大学院医歯薬学研究部(薬学系), 助教 (60550001)
Project Period (FY)	2015-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	ピペラジノン / 不斉触媒 / 不斉アルドール反応 / 環状炭酸エステル / 非対称化反応
Outline of Final Research Achievements	We investigated that development of novel asymmetric catalyst based on piperazinone derivatives. As a result, we demonstrated that novel piperazinone bearing a primary amino group could catalyze asymmetric aldol reaction between hydroxyacetone and p-nitrobenzaldehyde. In addition, novel piperazinone bearing a tertiary amino group was found to catalyze asymmetric desymmetrization of σ-symmetric cyclic carbonates.

Report

(3 results)