Molecular mechanism of the development of thymic epithelial cells
| Project/Area Number |
15K19130
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
OHIGASHI Izumi 徳島大学, 先端酵素学研究所(プロテオ), 准教授 (00596588)
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| Research Collaborator |
TAKAHAMA Yousuke
SAKATA Mie
UDDIN Myn
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 胸腺 / 獲得免疫 / 胸腺上皮細胞 |
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| Outline of Final Research Achievements |
The thymus is an organ that produces functionally competent T cells that protect us from pathogens and malignancies. Foxn1 is a transcription factor that is essential for thymus organogenesis; however, the direct target for Foxn1 to actuate thymic T cell production is unknown. Here we show that a Foxn1-binding cis-regulatory element promotes the transcription of β5t, which has an essential role in cortical thymic epithelial cells to induce positive selection of functionally competent CD8+ T cells. A point mutation in this genome element results in a defect in β5t expression and CD8+ T cell production in mice. The results reveal a Foxn1-β5t transcriptional axis that governs CD8+ T cell production in the thymus
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Foxnl-β5t transcriptional axis controls CD8+T cell production in the thymus.2017
Author(s)
Uddin, MM., Ohigashi, I., Motosugi, R., Nakayama, T., Sakata, M., Hamazaki, J., Nishito, Y., Rode, I., Tanaka, K., Takemoto, T., Murata, S., and Takahama, Y.
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Journal Title
Nat. Commun.
Volume: 8
Pages: 1-10
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Dynamic spatio-temporal contribution of single β5t+ cortical epithelial precursors to the thymus medulla.2016
Author(s)
Mayer CE, Zuklys S, Zhanybekova S, Ohigashi I, Teh HY, Sansom SN, Shikama-Dorn N, Hafen K, Macaulay IC, Deadman ME, Ponting CP, Takahama Y, Hollander GA
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Journal Title
European Journal of Immunology
Volume: 46
Pages: 846-856
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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