Identification of novel effluent biomarkers for peritoneal deterioration in peritoneal dialysis
Project/Area Number |
15K19187
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Laboratory medicine
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Research Institution | Juntendo University |
Principal Investigator |
Idei Mayumi 順天堂大学, 医学部, 非常勤助教 (40596623)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | 慢性腎臓病 / 腹膜障害 / 腹膜透析 / 腹膜劣化 / ERC/mesothelin / 腹膜傷害 |
Outline of Final Research Achievements |
The peritoneal deterioration is associated with encapsulating peritoneal sclerosis which is the most serious complication of peritoneal dialysis. We identified novel biomarkers in peritoneal effluent to predict peritoneal deterioration in peritoneal dialysis. ERC/mesothelin is expressed in normal mesothelial cells, and is cleaved by a furin-like protease into two fragments: secreted N-ERC/mesothelin and membrane-bound C-ERC/mesothelin. We examined whether ERC/mesothelin predicts peritoneal deterioration. There were significant correlation between peritoneal function (D/P Cr) and N-ERC/mesothelin in peritoneal effluent. In multivariate analysis, N-ERC/mesothelin in peritoneal effluent was identified as an independent predictor of peritoneal deterioration even after adjusting for age, duration of peritoneal dialysis, and glomerular filtration rate. We concluded that N-ERC/mesothelin in peritoneal effluent predicts peritoneal deterioration.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Changes in apolipoprotein E-containing high-density lipoprotein (HDL) have little impact on HDL-cholesterol measurements using homogeneous assays in normolipidemic and dyslipidemic subjects.2017
Author(s)
Sasamoto K, Hirayama S, Kon M, Seino U, Ueno T, Nagao Y, Hirayama A, Isshiki M, Idei M, Yano K, Miida T.
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Journal Title
Clin Chim Acta
Volume: 470
Pages: 56-63
DOI
Related Report
Peer Reviewed
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[Journal Article] Pancreatic lipase activity in overnight effluent predicts high transport status in peritoneal dialysis patients.2016
Author(s)
Idei M, Tabe Y, Hamada C, Miyake K, Takemura H, Io H, Wakita M, Horii T, Tomino Y, Ohsaka A, Miida T.
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Journal Title
Clin Chim Acta
Volume: 462
Pages: 65-70
DOI
Related Report
Peer Reviewed
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[Presentation] 血清クレアチニンが著明な偽高値を呈したIgM-MGUSの1例2015
Author(s)
出居 真由美, 三宅 一徳, 眞野 訓, 築根 豊, 脇田 満, 川上 美由紀, 堀井 隆, 杉原 匡美, 田部 陽子, 富野 康日己, 小松 則夫, 大坂 顯通, 三井田 孝
Organizer
第62回日本臨床検査医学会学術集会
Place of Presentation
長良川国際会議場・岐阜都ホテル (岐阜市)
Year and Date
2015-11-20
Related Report
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[Presentation] 巨核球の増加と大型血小板を認めたWiskott-Aldrich症候群の一例2015
Author(s)
藍 智彦, 出居 真由美, 堀内 祐紀, 佐藤 尚武, 藤村 純也, 東海林 宏道, 池野 充, 清水 俊明, 笹原 洋二, 森尾 友宏, 田部 陽子, 三井田 孝
Organizer
第62回日本臨床検査医学会学術集会
Place of Presentation
長良川国際会議場・岐阜都ホテル (岐阜市)
Year and Date
2015-11-20
Related Report
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