| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
We proposed a statistical criterion to detect drug-drug interactions causing adverse drug reactions in spontaneous reporting systems. The proposed criterion controlled false positives at an acceptable level and had higher sensitivity than that of an existing criterion when events were rare. We also applied the proposed criterion to a spontaneous reporting system database in order to explore drug-drug interactions that result in hypoglycemia and rhabdomyolysis. We detected combination therapy with the antidiabetic, antihypertensive, and antihyperlipidemic drugs as potential interactions that could result in hypoglycemia and rhabdomyolysis.
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