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DPP4 inhibition ameliorates cardiac function by blocking the cleavage of HMGB1 in diabetic mice after myocardial infarction

Research Project

Project/Area Number 15K19390
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Cardiovascular medicine
Research InstitutionFukushima Medical University

Principal Investigator

Yuichi Nakamura  福島県立医科大学, 医学部, 博士研究員 (10745798)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsDPP4 inhibitor / Myocardial infarction / HMGB1 / cardiac remodeling / angiogenesis / DPP4 / 心筋梗塞 / 血管新生 / インクレチン / 増殖因子
Outline of Final Research Achievements

DPP4 activity was increased in the diabetic state and blocked by anagliptin administration. The HMGB1 plasma levels were reduced in the diabetic TG compared with the non-diabetic TG mice, but DPP4 inhibition with anagliptin increased HMGB1 plasma levels in the diabetic TG mice. The infarct area was significantly larger in the diabetic TG than in the non-diabetic TG mice, and was reduced by DPP4 inhibition. Cardiac function, angiogenesis, and VEGF expression were impaired in the diabetic TG mice, but ameliorated by the DPP4 inhibition to levels similar to those found in the non-diabetic TG mice.
The DPP4 inhibitor ameliorated cardiac function by inhibiting the inactivation of HMGB1 in diabetic mice after MI.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (33 results)

All 2017 2016 2015

All Journal Article (7 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 7 results,  Open Access: 7 results,  Acknowledgement Compliant: 2 results) Presentation (26 results) (of which Int'l Joint Research: 7 results)

  • [Journal Article] DPP4 inhibition ameliorates cardiac function by blocking the cleavage of HMGB1 in diabetic mice after myocardial infarction2017

    • Author(s)
      Akihiko Sato、Yuichi Nakamura
    • Journal Title

      International Heart Journal

      Volume: 印刷中

    • NAID

      130006179202

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The association between circulating anti-angiogenic isoform of vascular endothelial growth factor and clinical profiles in patients with peripheral artery disease2016

    • Author(s)
      Sato A, Yoshihisa A, Yokokawa T, Shimizu T, Nakamura Y, Misaka T, Kamioka M, Kaneshiro T, Suzuki S, Kunii H, Saitoh S, Takeishi Y
    • Journal Title

      Int J Cardiol

      Volume: 207 Pages: 368-369

    • DOI

      10.1016/j.ijcard.2016.01.189

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] High Mobility Group Box 1 Promotes Angiogenesis from Bone Marrow-derived Endothelial Progenitor Cells after Myocardial Infarction2015

    • Author(s)
      Nakamura Y, Suzuki S, Shimizu T, Miyata M, Saitoh S, Kubota I, Takeishi Y
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 22 Issue: 6 Pages: 570-581

    • DOI

      10.5551/jat.27235

    • NAID

      130005078031

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of Peripheral Artery Disease on Prognosis in Hospitalized Heart Failure Patients2015

    • Author(s)
      Nakamura Y, Kunii H, Yoshihisa A, Takiguchi M, Shimizu T, Yamauchi H, Iwaya S, Owada T, Abe S, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
    • Journal Title

      Circulation Journal

      Volume: 79 Issue: 4 Pages: 785-793

    • DOI

      10.1253/circj.CJ-14-1280

    • NAID

      130005130257

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association of hypocalcemia with mortality in hospitalized patients with heart failure and chronic kidney disease2015

    • Author(s)
      Miura S, Yoshihisa A, Takiguchi M, Shimizu T, Nakamura Y, Yamauchi H, Iwaya S, Owada T, Miyata M, Abe S, Sato T, Suzuki S, Oikawa M, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
    • Journal Title

      Journal of Cardiac Failure

      Volume: 21 Issue: 8 Pages: 621-627

    • DOI

      10.1016/j.cardfail.2015.04.015

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Relationship of hyperuricemia with mortality in heart failure patients with preserved ejection fraction2015

    • Author(s)
      Shimizu T, Yoshihisa A, Kanno Y, Takiguchi M, Sato A, Miura S, Nakamura Y, Yamauchi H, Owada T, Abe S, Sato T, Suzuki S, Oikawa M, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
    • Journal Title

      American Journal of Physiology-Heart and Circulatory Physiology

      Volume: 309 Issue: 7 Pages: H1123-H1129

    • DOI

      10.1152/ajpheart.00533.2015

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cardio-protective effects of pentraxin 3 produced from bone marrow-derived cells against ischemia/reperfusion injury2015

    • Author(s)
      Shimizu T, Suzuki S, Sato A, Nakamura Y, Ikeda K, Saitoh S, Misaka S, Shishido T, Kubota I, Takeishi Y
    • Journal Title

      Journal of Molecular and Cellular Cardiology

      Volume: 89 Pages: 306-313

    • DOI

      10.1016/j.yjmcc.2015.10.013

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] DPP4 inhibition ameliorates cardiac function by blocking the cleavage of HMGB1 in diabetic mice after myocardial infarction2017

    • Author(s)
      Akihiko Sato、Yuichi Nakamura
    • Organizer
      第81回日本循環器病学術総会
    • Place of Presentation
      石川県金沢市
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] Beneficial impact of dipeptidyl-peptidase-4 inhibitors on mortality of hospitalized heart failure patients with diabetes mellitus.2016

    • Author(s)
      Sato A, Yoshihisa A, Kanno Y, Takiguchi M, Miura S, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Oikawa M, Sakamoto N, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2016-03-20
    • Related Report
      2015 Research-status Report
  • [Presentation] Hyperuricemia is a prognostic predictor of all-cause mortality in heart failure with preserved ejection fraction.2016

    • Author(s)
      Shimizu T, Yoshihisa A, Takiguchi M, Miura S, Sato A, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Oikawa M, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2016-03-20
    • Related Report
      2015 Research-status Report
  • [Presentation] Impact of n-3 polyunsaturated fatty acids on mortality of patients with hospitalized heart failure patients.2016

    • Author(s)
      Watanabe S, Yoshihisa A, Kanno Y, Takiguchi M, Miura S, Sato A, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Oikawa M, Sakamoto N, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2016-03-20
    • Related Report
      2015 Research-status Report
  • [Presentation] Prognostic impact of periodic leg movements in hospitalized heart failure patients.2016

    • Author(s)
      Kanno Y, Yoshihisa A, Takiguchi M, Miura S, Sato A, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Oikawa M, Sakamoto N, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2016-03-20
    • Related Report
      2015 Research-status Report
  • [Presentation] The association between plasma level of antiangiogenic isoform of vascular endothelial growth factor and clinical profile of peripheral artery disease.2016

    • Author(s)
      Sato A, Yoshihisa A, Kanno Y, Takiguchi M, Miura S, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Oikawa M, Sakamoto N, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2016-03-20
    • Related Report
      2015 Research-status Report
  • [Presentation] The CHA2DS2-VASc score predicts high mortality in hospitalized heart failure patients.2016

    • Author(s)
      Watanabe S, Yoshihisa A, Kanno Y, Takiguchi M, Miura S, Sato A, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Oikawa M, Sakamoto N, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2016-03-20
    • Related Report
      2015 Research-status Report
  • [Presentation] Associations of insomnia with prognosis in hospitalized heart failure patients.2016

    • Author(s)
      Kanno Y, Yoshihisa A, Takiguchi M, Miura S, Sato A, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Oikawa M, Sakamoto N, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2016-03-18
    • Related Report
      2015 Research-status Report
  • [Presentation] eneficial impact of dipeptidyl-peptidase-4 inhibitors on mortality of patients with hospitalized heart failure patients with diabetes mellitus.2015

    • Author(s)
      Sato A, Yoshihisa A, Kanno Y, Takiguchi M, Miura S, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Oikawa M, Sakamoto N, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y.
    • Organizer
      Scientific Sessions of American Heart Association 2015
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2015-11-07
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Cardio-protective effects of pentraxin 3 produced from bone marrow-derived cells against ischemia/reperfusion injury.2015

    • Author(s)
      Shimizu T, Suzuki S, Sato A, Nakamura Y, Saitoh S, Mantovani A, Shishido T, Kubota I, Takeishi Y.
    • Organizer
      Scientific Sessions of American Heart Association 2015
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2015-11-07
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Impact of n-3 polyunsaturated fatty acids on mortality of patients with hospitalized heart failure patients.2015

    • Author(s)
      Watanabe S, Yoshihisa A, Kanno Y, Takiguchi M, Miura S, Sato A, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Oikawa M, Sakamoto N, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y.
    • Organizer
      Scientific Sessions of American Heart Association 2015
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2015-11-07
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Impact of serum uric acid on mortality in heart failure with preserved ejection fraction.2015

    • Author(s)
      himizu T, Yoshihisa A, Takiguchi M, Miura S, Sato A, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Oikawa M, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y.
    • Organizer
      Scientific Sessions of American Heart Association 2015
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2015-11-07
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Prognostic impact of periodic leg movements in hospitalized heart failure patients.2015

    • Author(s)
      Kanno Y, Yoshihisa A, Takiguchi M, Miura S, Sato A, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Oikawa M, Sakamoto N, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y.
    • Organizer
      Scientific Sessions of American Heart Association 2015
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2015-11-07
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] The association between plasma levels of anti-angiogenic isoform of vascular endothelial growth factor and clinical profiles of peripheral artery disease.2015

    • Author(s)
      Sato A, Yoshihisa A, Kanno Y, Takiguchi M, Miura S, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Oikawa M, Sakamoto N, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y.
    • Organizer
      Scientific Sessions of American Heart Association 2015
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2015-11-07
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] The CHA2DS2-VASc score predicts high mortality in hospitalized heart failure patients.2015

    • Author(s)
      Watanabe S, Yoshihisa A, Kanno Y, Takiguchi M, Miura S, Sato A, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Oikawa M, Sakamoto N, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y.
    • Organizer
      Scientific Sessions of American Heart Association 2015
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2015-11-07
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Association between hyperuricemia and mortality in heart failure patients with preserved ejection fraction2015

    • Author(s)
      Shimizu T, Yoshihisa A, Takiguchi M, Miura S, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Takeishi Y.
    • Organizer
      第19回日本心不全学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-10-22
    • Related Report
      2015 Research-status Report
  • [Presentation] RCA入口部の高度石灰化亜完全閉塞に対しRotablatorが有効であった症例.2015

    • Author(s)
      君島勇輔, 國井浩行, 肱岡奈保子, 中村裕一, 阿部諭史, 神山美之, 坂本信雄, 八巻尚洋, 中里和彦, 鈴木 均, 齋藤修一, 竹石恭知
    • Organizer
      第24回日本心血管インターベンション治療学会
    • Place of Presentation
      福岡
    • Year and Date
      2015-07-30
    • Related Report
      2015 Research-status Report
  • [Presentation] 心不全患者における末梢動脈疾患の検討.2015

    • Author(s)
      中村裕一, 國井浩行, 義久精臣, 清水竹史, 大和田卓史, 坂本信雄, 八巻尚洋, 杉本浩一, 中里和彦, 鈴木 均, 齋藤修一, 竹石恭知.
    • Organizer
      第24回日本心血管インターベンション治療学会
    • Place of Presentation
      福岡
    • Year and Date
      2015-07-30
    • Related Report
      2015 Research-status Report
  • [Presentation] High mobility group box 1 promotes angiogenesis from bone marrow-derived endothelial progenitor cells after myocardial infarction2015

    • Author(s)
      Yuichi Nakamura, Satoshi Suzuki, Takeshi Shimizu, Shu-ichi Saitoh, Yasuchika Takeishi
    • Organizer
      第79回日本循環器学会学術集会
    • Place of Presentation
      大阪市
    • Year and Date
      2015-04-24
    • Related Report
      2015 Research-status Report
  • [Presentation] Peripheral Artery Disease Predicts Adverse Prognosis of Heart Failure Patients2015

    • Author(s)
      Yuichi Nakamura, Akiomi Yoshihisa, Hiroyuki Kunii, Takeshi Shimizu, Hiroyuki Yamauchi, Satoshi Abe, Satoshi Suzuki, Kazuhiko Nakazato, Hitoshi Suzuki, Shu-ichi Saitoh, Yasuchika Takeishi
    • Organizer
      第79回日本循環器学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24
    • Related Report
      2015 Research-status Report
  • [Presentation] Impact of body mass index on mortality in heart failure patients2015

    • Author(s)
      Takiguchi M, Yoshihisa A, Miura S, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Oikawa M, Kobayashi A, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
    • Organizer
      第79回日本循環器学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24
    • Related Report
      2015 Research-status Report
  • [Presentation] mpact of hypocalcemia on mortality of patients with heart failure and chronic kidney disease2015

    • Author(s)
      Miura S, Yoshihisa A, Takiguchi M, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
    • Organizer
      第79回日本循環器学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24
    • Related Report
      2015 Research-status Report
  • [Presentation] Impact of insomnia on prognosis in hospitalized heart failure patients2015

    • Author(s)
      Takiguchi M, Yoshihisa A, Miura S, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
    • Organizer
      第79回日本循環器学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24
    • Related Report
      2015 Research-status Report
  • [Presentation] Impact of peripheral artery disease on prognosis in patients with heart failure2015

    • Author(s)
      Yoshihisa A, Nakamura Y, Kunii H, Takeishi Y
    • Organizer
      第79回日本循環器学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24
    • Related Report
      2015 Research-status Report
  • [Presentation] Impact of serum uric acid on mortality in heart failure with preserved ejection fraction.2015

    • Author(s)
      Shimizu T, Yoshihisa A, Takiguchi M, Miura S, Nakamura Y, Owada T, Yamauchi H, Abe S, Suzuki S, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y.
    • Organizer
      第79回日本循環器学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24
    • Related Report
      2015 Research-status Report
  • [Presentation] Myocardial infarct size quantification in mice using pinhole single-photon emission computed tomography.2015

    • Author(s)
      Shimizu T, Nakamura Y, Suzuki S, Kubo H, Ito H, Shishido F, Takenoshita S, Takeishi Y.
    • Organizer
      第79回日本循環器学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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