Breath analysis in heart failure

• Project/Area Number: 15K19401
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Fukushima Medical University (2016-2017); National Cardiovascular Center Research Institute (2015)
• Principal Investigator: Yokokawa Tetsuro 福島県立医科大学, 医学部, 博士研究員 (80748773)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 心不全 / 呼気検査 / アセトン / 呼気アセトン / 糖尿病 / バイオマーカー / 呼気ガス

Outline of Final Research Achievements

We examined the significance of breath analysis in heart failure. Breath acetone analysis was performed in 102 patients of heart failure. As a result, hemodynamics by cardiac catheterization was associated with breath acetone concentration. Among diabetic patients, breath acetone concentration was significantly higher in patients with heart failure than patients without heart failure. Levels of breath acetone concentration were decreased after treatment in patients with acute decompensated heart failure. Breath acetone concentration is a novel non-invasive biomarker in patients with heart failure.

Research Products

• [Journal Article] Associations between acylcarnitine to free carnitine ratio and adverse prognosis in heart failure patients with reduced or preserved ejection fraction. (2018)
  • Author(s): Yoshihisa A, Watanabe S, Yokokawa T, Misaka T, Sato T, Suzuki S, Oikawa M, Kobayashi A, Takeishi Y
  • Journal Title: ESC Heart Failure Volume: 4 Issue: 3 Pages: 360-364
  • DOI: 10.1002/ehf2.12176
  • Peer Reviewed / Open Access
• [Journal Article] Impact of nutritional indices on mortality in patients with heart failure. (2018)
  • Author(s): Yoshihisa A, Kanno Y, Watanabe S, Yokokawa T, Abe S, Miyata M, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Suzuki H, Ishida T, Takeishi Y:
  • Journal Title: Open Heart Volume: 5 Issue: 1 Pages: e000730-e000730
  • DOI: 10.1136/openhrt-2017-000730
  • Peer Reviewed / Open Access
• [Journal Article] Elevated exhaled acetone concentration in stage C heart failure patients with diabetes mellitus (2017)
  • Author(s): Yokokawa T, Sato T, Suzuki S, Oikawa M, Yoshihisa A, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Ishida T, Shimouchi A, Takeishi Y
  • Journal Title: BMC Cardiovasc Disord Volume: 17 Issue: 1 Pages: 280-280
  • DOI: 10.1186/s12872-017-0713-0
  • Peer Reviewed / Open Access
• [Journal Article] Change of Exhaled Acetone Concentration in a Diabetic Patient with Acute Decompensated Heart Failure (2017)
  • Author(s): Yokokawa T, Ichijo Y, Houtsuki Y, Matsumoto Y, Oikawa M, Yoshihisa A, Sugimoto K, Nakazato K, Suzuki H, Saitoh S, Shimouchi A, Takeishi Y
  • Journal Title: International Heart Journal Volume: 58 Issue: 5 Pages: 828-830
  • DOI: 10.1536/ihj.16-556
  • NAID: 130006179204
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed / Open Access
• [Journal Article] Clinical impact of the presence of macrophages in endomyocardial biopsies of patients with dilated cardiomyopathy. (2017)
  • Author(s): Nakayama T, Sugano Y, et al.
  • Journal Title: Eur J Heart Fail. Volume: 19 Issue: 4 Pages: 490-498
  • DOI: 10.1002/ejhf.767
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Liver fibrosis score predicts mortality in heart failure patients with preserved ejection fraction. (2017)
  • Author(s): Yoshihisa A, Sato Y, Yokokawa T, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Saitoh SI, Takeishi Y
  • Journal Title: ESC Heart Fail Volume: 5 Issue: 2 Pages: 162-270
  • DOI: 10.1002/ehf2.12222
  • Peer Reviewed / Open Access
• [Journal Article] DPP4 Inhibition Ameliorates Cardiac Function by Blocking the Cleavage of HMGB1 in Diabetic Mice After Myocardial Infarction (2017)
  • Author(s): Sato A, Suzuki S, Watanabe S, Shimizu T, Nakamura Y, Misaka T, Yokokawa T, Shishido T, Saitoh SI, Ishida T, Kubota I, Takeishi Y
  • Journal Title: International Heart Journal Volume: 58 Issue: 5 Pages: 778-786
  • DOI: 10.1536/ihj.16-547
  • NAID: 130006179202
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed / Open Access
• [Journal Article] Liver stiffness assessed by Fibrosis-4 index predicts mortality in patients with heart failure. (2017)
  • Author(s): Sato Y, Yoshihisa A, Kanno Y, Watanabe S, Yokokawa T, Abe S, Misaka T, sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Saitoh S, Takeishi Y
  • Journal Title: Open Heart Volume: 4 Issue: 1 Pages: e000598-e000598
  • DOI: 10.1136/openhrt-2017-000598
  • Peer Reviewed / Open Access
• [Journal Article] Decreased cardiac mortality with nicorandil in patients with ischemic heart failure. (2017)
  • Author(s): Yoshihisa A, Sato Y, Watanabe S, Yokokawa T, Sato T, Suzuki S, Oikawa M, Kobayashi A, Takeishi Y
  • Journal Title: BMC Cardiovasc Disord Volume: 17 Issue: 1 Pages: 141-141
  • DOI: 10.1186/s12872-017-0577-3
  • Peer Reviewed / Open Access
• [Journal Article] Associations of acid suppressive therapy with cardiac mortality in heart failure patients. (2017)
  • Author(s): Yoshihisa A, Takiguchi M, Kanno Y, Sato A, Yokokawa T, Miura S, Abe S, Misaka T, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: J Am Heart Assoc Volume: 6 Issue: 5
  • DOI: 10.1161/jaha.116.005110
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Change of exhaled acetone concentration in a diabetic patient with acute decompensated heart failure (2017)
  • Author(s): Tetsuro Yokokawa, Yasuhiro Ichijo, Yu Houtsuki, Yoshiyuki Matsumoto, Masayoshi Oikawa, Akiomi Yoshihisa, Koichi Sugimoto, Kazuhiko Nakazato, Hitoshi Suzuki, Shu-ichi Saitoh, Akito Shimouchi, Yasuchika Takeishi
  • Journal Title: International Heart Journal Volume: in press
  • NAID: 130006179204
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Clinical features in extremely elderly patients with heart failure (2017)
  • Author(s): Tetsuro Yokokawa, Akiomi Yoshihisa, Yuki Kanno, Takamasa Sato, Satoshi Suzuki, Tomofumi Misaka, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Hitoshi Suzuki, Shu-ichi Saitoh, Yasuchika Takeishi
  • Journal Title: Geriatrics & Gerontology International Volume: in press
  • Peer Reviewed
• [Journal Article] A case of acute decompensated heart failure evaluated by series of exhaled acetone concentrations as noninvasive biomarker of heart failure severity (2016)
  • Author(s): Tetsuro Yokokawa, Yasuo Sugano, Akito Shimouchi, Atsushi Shibata, Takafumi Nakayama, Takahiro Ohara, Naoya Jinno, Hideaki Kanzaki, Toshihisa Anzai
  • Journal Title: International journal of cardiology Volume: 204 Pages: 112-113
  • DOI: 10.1016/j.ijcard.2015.11.173
  • Peer Reviewed
• [Journal Article] Significance of myocardial tenascin-C expression in left ventricular remodelling and long-term outcome in patients with dilated cardiomyopathy. (2016)
  • Author(s): Yokokawa T, Sugano Y, et al.
  • Journal Title: Eur J Heart Fail. Volume: in press Issue: 4 Pages: 375-385
  • DOI: 10.1002/ejhf.464
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The association between circulating anti-angiogenic isoform of vascular endothelial growth factor and clinical profiles in patients with peripheral artery disease (2016)
  • Author(s): Sato A, Yoshihisa A, Yokokawa T, Shimizu T, Nakamura Y, Misaka T, Kamioka M, Kaneshiro T, Suzuki S, Kunii H, Saitoh S, Takeishi Y
  • Journal Title: Int J Cardiol Volume: 207 Pages: 368-369
  • DOI: 10.1016/j.ijcard.2016.01.189
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Prosthetic valve dysfunction 35 years after mitral valve replacement with a Starr-Edwards caged-disc valve (2016)
  • Author(s): Tetsuro Yokokawa, Takahiro Ohara, Seiji Takashio, Mari Sakamoto, Yuko Wada, Kenji Nakamura, Hiroyuki Takahama, Makoto Amaki, Takuya Hasegawa, Yasuo Sugano, Hideaki Kanzaki, Satoshi Yasuda, Hisao Ogawa, Tomoyuki Fujita, Junjiro Kobayashi, Yuko Okamoto, Taka-aki Matsuyama, Hatsue Ishibashi-Ueda, Toshihisa Anzai
  • Journal Title: Internal Medicine Volume: 55 Pages: 479-483
  • NAID: 130005132627
  • Peer Reviewed / Open Access
• [Journal Article] Exhaled acetone concentration is related to hemodynamic severity in patients with non-ischemic chronic heart failure (2016)
  • Author(s): Tetsuro Yokokawa, Yasuo Sugano, Akito Shimouchi, Atsushi Shibata, Naoya Jinno, Toshiyuki Nagai, Hideaki Kanzaki, Takeshi Aiba, Kengo Kusano, Mikiyasu Shirai, Yasuchika Takeishi, Satoshi Yasuda, Hisao Ogawa, Toshihisa Anzai
  • Journal Title: Circulation journal Volume: 未
  • NAID: 130005147652
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Elevated exhaled acetone concentration in stage C heart failure patients with diabetes mellitus (2018)
  • Author(s): Tetsuro Yokokawa, Takamasa Sato, Satoshi Suzuki, Masayoshi Oikawa, Akiomi Yoshihisa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Takafumi Ishida, Akito Shimouchi, Yasuchika Takeishi
  • Organizer: 日本循環器学会
• [Presentation] Skin gas analysis in patients with cardiovascular diseases (2018)
  • Author(s): Tetsuro Yokokawa, Takamasa Sato, Satoshi Suzuki, Masayoshi Oikawa, Akiomi Yoshihisa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Takafumi Ishida, Yasuchika Takeishi
  • Organizer: 日本循環器学会
• [Presentation] Change of exhaled acetone concentration levels in patients with acute decompensated heart failure (2017)
  • Author(s): Yokokawa T, Sato T, Suzuki S, Oikawa M, Yoshihisa A, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh SI, Ishida T, Shimouchi A, Takeishi Y
  • Organizer: American Heart Association, Anaheim
  • Int'l Joint Research
• [Presentation] 生体ガス中におけるアセトン濃度の関連要因 (2017)
  • Author(s): 下内章人、横川哲朗、野瀬和利、神野直哉、奥村直也、谷口健太郎、菅野康夫、安斉俊久
  • Organizer: 第9回日本安定同位体・生体ガス医学応用学会 大会
• [Presentation] 超遅発性ステント血栓症に対して薬剤溶出性バルーンで治療し得た1例 (2017)
  • Author(s): 片平正隆、横川哲朗、中村裕一、清田寛
  • Organizer: 第42回日本心血管インターベンション学会
• [Presentation] 抗ミトコンドリア抗体陽性筋炎に合併した非虚血性心不全の1例 (2017)
  • Author(s): 片平正隆、横川哲朗、三浦俊輪、中村裕一、鈴木聡、山田慎哉、及川雅啓、竹石恭知
  • Organizer: 日本循環器学会 東北地方会
• [Presentation] Beneficial impact of nicorandil on mortality in patients with ischemic heart failure (2017)
  • Author(s): Tetsuro Yokokawa, Yu Sato, Akiomi Yoshihisa, Shunsuke Watanabe, Shunsuke Miura, Takamasa Sato, Satoshi Suzuki, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Shu-ichi Saitoh, Yasuchika Takeishi
  • Organizer: 日本循環器学会
• [Presentation] Pericellular amyloid infiltration in biopsy-proven cardiac amyloidosis (2016)
  • Author(s): Tetsuro Yokokawa, Yasuo Sugano, Taka-aki Matsuyama, Hideaki Kanzaki, Keiko Ohta-Ogo, Yoshihiko Ikeda, Hatsue Ishibashi-Ueda, Yasuchika Takeishi, Satoshi Yasuda, Toshihisa Anzai
  • Organizer: American Heart Association
  • Place of Presentation: New Orleans
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] 3．Plasma volume status predicts mortality in heart failure patients (2016)
  • Author(s): Tetsuro Yokokawa, Akiomi Yoshihisa, Yu Sato, Shunsuke Watanabe, Shunsuke Miura, Takamasa Sato, Satoshi Abe, Satoshi Suzuki, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Shu-ichi Saitoh, Yasuchika Takeishi
  • Organizer: American Heart Association
  • Place of Presentation: New Orleans
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Gender and prognostic significance of anemia in chronic heart failure (2016)
  • Author(s): Tetsuro Yokokawa, Akiomi Yoshihisa, Takamasa Sato, Satoshi Suzuki, Masayoshi Oikawa, Atushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Yasuchika Takeishi
  • Organizer: 日本心不全学会
  • Place of Presentation: 札幌
  • Year and Date: 2016-10-07
• [Presentation] Macrophages with M2 Phenotype Contribute to Fibrotic Ventricular Remodeling in Dilated Cardiomyopathy (2016)
  • Author(s): Takafumi Nakayama, Yasuo Sugano, Masao Takigami, Tetsuro Yokokawa, Toshiyuki Nagai, Hideaki Kanzaki, Keiko Ohgoh, Takaaki Matsuyama, Yoshihiko Ikeda, Hatsue Ishibashi-Ueda, Takeshi Nakatani, Satoshi Yasuda, Hisao Ogawa, Toshihisa Anzai
  • Organizer: 日本循環器学会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18
• [Presentation] Neutrophil to Lymphocyte Ratio is Associated with Heart Failure Severity and Prognosis in Patients with Idiopathic Dilated Cardiomyopathy (2016)
  • Author(s): Nobuhiko Ueda, Yasuo Sugano, Takafumi Nakayama, Tetsuro Yokokawa, Toshiyuki Nagai, Satoshi Yasuda, Hisao Ogawa, Toshihisa Anzai
  • Organizer: 日本循環器学会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18
• [Presentation] Association between Increased CRP Level and Myocardial Immune Activation in Patients with Dilated Cardiomyopathy (2016)
  • Author(s): Masashi Koga, Yasuo Sugano, Takafumi Nakayama, Tetsuro Yokokawa, Toshiyuki Nagai, Hideaki Kanzaki, Takaaki Matsuyama, Keiko Ohgoh, Yoshihiko Ikeda, Hatsue Ishibashi-Ueda, Satoshi Yasuda, Hisao Ogawa, Toshihisa Anzai
  • Organizer: 日本循環器学会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18
• [Presentation] Hydrogen Consumption is a Noninvasive Biomarker Predicting the Severity in Patients with Chronic Heart Failure (2016)
  • Author(s): Atsushi Shibata, Yasuo Sugano, Akito Shimouchi, Tetsuro Yokokawa, Hideaki Kanzaki, Takeshi Aiba, Kengo Kusano, Mikiyasu Shirai, Satoshi Yasuda, Hisao Ogawa, Toshihisa Anzai
  • Organizer: 日本循環器学会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18
• [Presentation] Exhaled Acetone Concentration is a Noninvasive Diagnostic Biomarker Related with Disease Severity in Patients with Chronic Heart Failure (2016)
  • Author(s): Tetsuro Yokokawa, Yasuo Sugano, Akito Shimouchi, Atsushi Shibata, Hideaki Kanzaki, Takeshi Aiba, Kengo Kusano, Mikiyasu Shirai, Satoshi Yasuda, Hisao Ogawa, Toshihisa Anzai
  • Organizer: 日本循環器学会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18
• [Presentation] 病理学的に診断されたAL型アミロイドーシスにおける致死性心室性不整脈の検討 (2015)
  • Author(s): 横川哲朗、菅野康夫、松山高明、高潮征爾、大郷恵子、神崎秀明、池田善彦、植田初江、安斉俊久
  • Organizer: 心筋生検研究会
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-11
• [Presentation] Exhaled acetone concentration is a novel noninvasive biomarker related with disease severity in patients with congestive heart failure (2015)
  • Author(s): Tetsuro Yokokawa, Yasuo Sugano, Akito Shimouchi, Naoya Jinno, Mikiyasu Shirai, Satoshi Yasuda, Hisao Ogawa, Toshihisa Anzai
  • Organizer: European Society of Cardiology
  • Place of Presentation: London, UK
  • Year and Date: 2015-08-29
  • Int'l Joint Research
• [Presentation] The relationship of myocardial tenascin-C expression with diabetes mellitus, left ventricular remodeling, and long-term prognosis in patients with dilated cardiomyopathy (2015)
  • Author(s): Tetsuro Yokokawa, Yasuo Sugano , Takafumi Nakayama , Masao Takigami , Toshiyuki Nagai , Hideaki Kanzaki , Takaaki Matsuyama , Keiko Ohgoh , Yoshihiko Ikeda , Hatsue Ishibashi-Ueda , Takeshi Nakatani , Satoshi Yasuda , Hisao Ogawa , Toshihisa Anzai
  • Organizer: 日本循環器学会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24
• [Presentation] Left ventricular wall thinning is an independent predictor of long-term prognosis in dilated cardiomyopathy (2015)
  • Author(s): Tetsuro Yokokawa, Yasuo Sugano , Takafumi Nakayama , Masao Takigami , Toshiyuki Nagai , Hideaki Kanzaki , Takaaki Matsuyama , Keiko Ohgoh , Yoshihiko Ikeda , Hatsue Ishibashi-Ueda , Takeshi Nakatani , Satoshi Yasuda , Hisao Ogawa , Toshihisa Anzai
  • Organizer: 日本循環器学会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24
• [Presentation] Poor Long-term Prognosis in Patients with Inflammatory Dilated Cardiomyopathy Diagnosed by Endomyocardial Biopsy (2015)
  • Author(s): Masao Takigami, Yasuo Sugano , Takafumi Nakayama , Tetsuro Yokokawa , Toshiyuki Nagai , Hideaki Kanzaki , Keiko Ohgoh , Takaaki Matsuyama , Yoshihiko Ikeda , Hatsue Ishibashi-Ueda , Takeshi Nakatani , Satoshi Yasuda , Hisao Ogawa , Toshihisa Anzai
  • Organizer: 日本循環器学会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24
• [Presentation] Prognostic Value of Peripheral Neutrophil to Lymphocyte Ratio in Patients with Newly-diagnosed Dilated Cardiomyopathy (2015)
  • Author(s): Nobuhiiko Ueda, Yasuo Sugano , Takafumi Nakayama , Tetsurou Yokokawa , Masao Takigami , Toshiyuki Nagai , Satoshi Yasuda , Hisao Ogawa , Toshihisa Anzai
  • Organizer: 日本循環器学会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24