| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Outline of Final Research Achievements |
Bone-mineral metabolic abnormalities associated with Chronic Kidney Disease (CKD) are "multiple organ diseases" caused by failure of phosphate metabolism. In this study, we analyzed the mechanism of abnormal mineral metabolism across multiple organs and its therapeutic effects. In CKD-induced vitamin D receptor (VDR)-deficient mice, suppression of blood urea nitrogen and phosphorus elevation was observed, suggesting that the inhibition of VDR is effective for renal protection. Furthermore, the importance of tissue selective VDR action and the therapeutic effects by low phosphate diet or vitamin D administration are evaluated.
Also, we comprehensively detected metabolic (biological) products using metabolome analyzers, and obtained enormous data. Based on these results, we are attempting to identify early diagnostic markers for CKD-Mineral Bone Disorder and predictive markers for multiple organ complications.
|
