| Project/Area Number |
15K19627
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 機能的近赤外線分光法 / 注意欠如・多動障害 / 自閉症スペクトラム / 塩酸メチルフェニデート徐放剤 / 抑制機能課題 / fNIRS / ADHD |
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| Outline of Final Research Achievements |
We examined the neural substrate of the effects of methylphenidate (MPH) on inhibition control in medication-naive ADHD and ADHD with ASD children using fNIRS in a randomized, double-blind, placebo-controlled, crossover design. We investigated cortical activation in the right inferior or middle frontal gyrus (IFG/MFG). In the ADHD without ASD group, unmedicated children exhibited no activation in right IFG/MFG, but MPH medication led to increased right IFG/MFG activation. In the ADHD with ASD group, right IFG/MFG activation was observed before taking MPH, but MPH medication resulted in decreased right IFG/MFG activation. Behavioral assessment showed a significant improvement in both groups one month after oral administration of MPH. In cases where MPH was effective, these results suggest that ADHD with ASD is not simply a mixture of ADHD and ASD pure disorders, but rather that it has its own distinct neuropathology. We will examine cases in which MPH is ineffective as a next step.
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