The role of B-cell expression in hepatic ischemia reperfusion injury

• Project/Area Number: 15K19857
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General surgery
• Research Institution: The University of Tokushima
• Principal Investigator: SAITO Yu 徳島大学, 大学院医歯薬学研究部(医学系), 助教 (50548675)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: B細胞 / 肝虚血再灌流障害 / 肝虚血再灌流傷害 / B cell

Outline of Final Research Achievements

Liver ischemia-reperfusion (I/R) injury is one of critical problems to overcome in hepatectomy. Liver B cells among immune cells were focused on for the first time involved in I/R injury. Intrahepatic B cells might increase throughout CXCL13 / CXCR5 axis at relatively early time (2 hours) after reperfusion, and B cells can become therapeutic target in liver I/R injury.

Research Products

• [Journal Article] Mechanism of impairment on liver regeneration in elderly patients: Role of hepatic stellate cell function. (2017)
  • Author(s): Saito Y, Morine Y, Shimada M.
  • Journal Title: Hepatology Research Volume: 印刷中 Issue: 6 Pages: 505-513
  • DOI: 10.1111/hepr.12872
  • Peer Reviewed
• [Journal Article] Loss of Secreted Frizzled-Related Protein-1 expression is associated with poor prognosis in intrahepatic cholangiocarcinoma. (2016)
  • Author(s): Davaadorj M, Saito Y, Morine Y, Ikemoto T, Imura S, Takasu C, Yamada S, Hiroki T, Yoshikawa M, Shimada M.
  • Journal Title: Eur J Surg Oncol. Volume: 43 Issue: 2 Pages: 344-350
  • DOI: 10.1016/j.ejso.2016.11.017
  • Peer Reviewed
• [Journal Article] A Nonhematopoietic Erythropoietin Analogue, ARA 290, Inhibits Macrophage Activation and Prevents Damage to Transplanted Islets. (2016)
  • Author(s): Watanabe M, Lundgren T, Saito Y, Cerami A, Brines M, Ostenson CG, Kumagai-Braesch M.
  • Journal Title: Transplantation. Volume: 36 Issue: 3 Pages: 659-664
  • DOI: 10.1097/tp.0000000000001026
  • Peer Reviewed
• [Journal Article] Liver regeneration after splenectomy in patients with liver cirrhosis. (2016)
  • Author(s): Yamada S, Morine Y, Imura S, Ikemoto T, Arakawa Y, Iwahashi S, Saito Y, Yoshikawa M, Teraoku H, Shimada M.
  • Journal Title: Hepatolgy research Volume: 印刷中 Issue: 5 Pages: 443-449
  • DOI: 10.1111/hepr.12573
  • Peer Reviewed
• [Journal Article] Dysfunction of liver regeneration in aged liver after partial hepatectomy. (2015)
  • Author(s): Enkhbold C1, Morine Y, Utsunomiya T, Imura S, Ikemoto T, Arakawa Y, Saito Y, Yamada S, Ishikawa D, Shimada M.
  • Journal Title: Journal of Gastroenterology and Hepatology Volume: - Issue: 7 Pages: 1217-1224
  • DOI: 10.1111/jgh.12930
  • Peer Reviewed
• [Presentation] PDに対するModified de-rotationを用いた“Complate artery-firstn approach”. (2016)
  • Author(s): 齋藤 裕
  • Organizer: 第41回日本外科系連合学会学術集会
  • Place of Presentation: ナレッジキャピタル(大阪府大阪市)
  • Year and Date: 2016-06-15
• [Presentation] HDAC阻害剤は脂肪由来幹細胞からインスリン分泌細胞への分化誘導を促進する (2016)
  • Author(s): 齋藤 裕
  • Organizer: 第116回日本外科学会定期学術集会
  • Place of Presentation: 大阪国際会議場(大阪府大阪市)
  • Year and Date: 2016-04-14
• [Presentation] The usefulness of peri-operative nutritional assessment in hepatobiliary pancreatic surgery using body composition analyzer and subjective global assessment. (2015)
  • Author(s): 齋藤 裕
  • Organizer: Clinical Congress of American College of Surgeons 2015
  • Place of Presentation: McCormick Place （Chicago, USA）
  • Year and Date: 2015-10-06
  • Int'l Joint Research
• [Presentation] The liver regeneration of left lobe after right liver resection;the comparison among caudate lobe,lateral and median segment. (2015)
  • Author(s): 齋藤 裕
  • Organizer: 17th Congress of the European Society for Organ Transplantation (ESOT)
  • Place of Presentation: Square-Brussels Meeting centre(Brussels, Bergium)
  • Year and Date: 2015-09-14
  • Int'l Joint Research
• [Presentation] 肝胆膵外科手術における周術期栄養評価の有用性に関する研究-体成分分析装置と主観的包括的アセスメント- (2015)
  • Author(s): 齋藤裕,安井苑子,吉川雅登,寺奥大貴,山田眞一郎,岩橋衆一,荒川悠佑,池本哲也,森根裕二,居村暁,濱田康弘,島田光生
  • Organizer: 第27回日本肝胆膵外科学会
  • Place of Presentation: ホテル グランパシフィック LE DAIBA（東京都港区）
  • Year and Date: 2015-06-12
• [Presentation] 大量肝切除モデルラットにおける茶Catechinの効果 (2015)
  • Author(s): 齋藤裕
  • Organizer: 第30回日本shock学会総会
  • Place of Presentation: 京王プラザホテル八王子(東京都八王子市)
  • Year and Date: 2015-05-22